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西吡氯铵含漱液治疗口腔念珠菌感染的效果观察

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目的 探讨西吡氯铵含漱液治疗口腔念珠菌感染的临床疗效.方法 选取陕西省勉县中医院2015年4月~2017年4月收治的口腔念珠菌感染患者45例作为研究对象,其中接受西吡氯铵含漱液治疗者24例,设为观察组;接受聚维酮碘含漱液治疗者21例,设为对照组.经治疗后比较2组患者的口腔疼痛评分、黏膜萎缩评分和黏膜红斑评分;采用HAMA焦虑量表、HAMD抑郁量表评估其心理应激状态,比较2组患者的HAMA评分、HAMD评分、血糖和胰岛素水平;比较2组患者治疗后口腔黏膜镜检阳性率和不良反应发生率.结果 经治疗后观察组口腔疼痛评分、黏膜萎缩评分和黏膜红斑评分均显著低于对照组,差异均有统计学意义(P<0.05).治疗后观察组HAMA评分、HAMD评分、血糖水平均显著低于对照组,胰岛素水平高于对照组,比较差异均有统计学意义(P<0.05).镜检结果显示,观察组口腔黏膜镜检阳性5例,阳性率为20.83%(5/24);对照组口腔黏膜镜检阳性11例,阳性率为52.38%(11/21).观察组口腔黏膜镜检阳性率显著低于对照组,比较差异有统计学意义(P<0.05).观察组患者治疗期间未见明显不良反应,对照组仅出现口腔黏膜充血1例,但可耐受,疗程结束后自行消失.2组不良反应发生率比较无统计学差异(P>0.05).结论 采用西吡氯铵含漱液治疗口腔念珠菌感染可缓解口腔疼痛、黏膜萎缩、红斑症状和应激状态,有效控制口腔感染,且无明显不良反应,安全性高.
Observation on the effect of cetylpyridine chloride gargle in the treatment of oral Candida infection
Objective To investigate the clinical efficacy of cetylpyridinium chloride gargle in the treatment of oral candidiasis.Methods Collected 45 cases of oral candidiasis patients admitted in our hospital from April 2015 to April 2017.Among them, 24 patients were treated with cetylpyridinium chloride gargle and treated as observation group.Rinse treatment in 21 cases, set as the control group.The oral pain score, mucosal atrophy score and mucosal erythema score were compared between the two groups.The HAMA anxiety scale and HAMD depression scale were used to evaluate the psychological stress.The HAMA score, HAMD score, blood glucose and blood glucose were compared between the two groups.Insulin levels were compared between the two groups of patients after oral mucosal examination positive rate and the incidence of adverse reactions.Results After treatment, the oral pain score, mucosal atrophy score and mucosal erythema score were significantly lower in the observation group than in the control group, the difference was statistically significant(P<0.05).The HAMA score, HAMD score and blood glucose level were significantly lower in the observation group than in the control group, the insulin level was higher than the control group, the difference was statistically significant(P<0.05).The positive rate was 20.83%(5/24)in the observation group and 52.38%(11/21)in the control group.The positive rate of oral mucosal examination in the observation group was significantly lower than that in the control group, the difference was statistically significant(P<0.05).There were no obvious adverse reactions during the treatment group.In the control group, only one case of oral mucosal congestion was found, but it was tolerable and disappeared after treatment.There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The use of cetylpyridinium chloride gargle in the treatment of oral candidiasis can relieve oral pain, mucosal atrophy, erythema symptoms and stress state, effective control of oral infection, and no significant adverse reactions、high safety.

cetylpyridine chloride garglepovidone iodine rinseoral candidiasisstress state

李银娟、高卫琪

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陕西省勉县中医院 口腔科,陕西 汉中 724200

西安市莲湖区环西社区卫生服务中心,陕西 西安 710068

西吡氯铵含漱液 聚维酮碘含漱液 口腔念珠菌感染 应激状态

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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