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硝酸甘油联合阿替洛尔治疗冠心病的临床疗效及安全性分析

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目的 探讨硝酸甘油联合阿替洛尔治疗冠心病的临床疗效及安全性分析.方法 收集2014年2月~2016年11月在本院治疗的冠心病患者114例进行分析,将患者随机分为试验组和对照组各57例,其中试验组患者采用硝酸甘油联合阿替洛尔进行治疗,对照组患者采用硝酸甘油进行治疗,观察2组患者的治疗效果,比较2组患者在治疗过程中的不良反应率.结果 治疗后试验组患者症状治疗总有效率为93.0%明显高于对照组总有效率78.9%,差异具有统计学意义(P<0.05);试验组的心电图治疗效果总有效率为89.5%明显高于对照组73.7%,差异具有统计学意义(P<0.05);试验组发生肠胃不适、头痛头晕、低血压反应等不良反应2例(3.5%)明显低于对照组发生不良反应11例(19.3%),差异具有统计学意义(P<0.05).结论 硝酸甘油联合阿替洛尔治疗冠心病具有良好的临床疗效和安全性.
The clinical efficacy and safety of nitroglycerin combined with atenolol in the treatment of coronary heart disease
Objective To study the clinical efficacy and safety of nitroglycerin combined with atenolol in the treatment of coronary heart disease.Methods From February 2014 to November 2016, 114 cases of coronary heart disease patients treated in Zhongshan hospital were selected, all patients were randomly divided into experimental group and control group, the patients in experimental group were treated with nitroglycerin combined with atenolol, and the patients in control group were treated with nitroglycerin, the therapeutic effects of two groups were observed, the adverse reactions of the two groups were compared.Results After treatment, the total effective rate of the treatment group was 93% higher than that of the control group(78.9%), the difference was statistically significant(P< 0.05);The total effective rate of ECG in the experimental group was 89.5% higher than that in the control group(73.7%), the difference was statistically significant(P<0.05);There were 2 cases(3.5%)of adverse reactions in the experimental group and there were 11 cases(19.3%)of adverse reactions in the control group, which was significantly lower in the experimental group than that in the control group, the difference was statistically significant(P<0.05).Conclusion Phenyl bromide Malone and colchicine had good clinical curative effect in the treatment of chronic gout.

nitroglycerinatenololclinical efficacysafety

刘瑜

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浙江省中山医院 药剂科,浙江 杭州 310005

硝酸甘油 阿替洛尔 临床疗效 安全性

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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