首页|长期小剂量米非司酮治疗子宫肌瘤的疗效观察

长期小剂量米非司酮治疗子宫肌瘤的疗效观察

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目的 观察长期小剂量米非司酮治疗子宫肌瘤的疗效.方法 选取2016年3月~2016年12月在浙江海盐县妇幼保健院就诊的120例子宫肌瘤患者为研究对象,采用小剂量米非司酮长期服用,观察治疗后的子宫大小、卵泡刺激素、肌瘤大小、黄体生成素、雌激素等多项临床指标,以及对患者子宫内膜的影响.结果 治疗后,患者子宫肌瘤情况明显好转.与此同时,患者在临床症状上均有一定程度的改善,在用药半年后卵泡刺激素、黄体生成素、雌激素水平明显下降,且尚无其他明显的不良反应.所选患者中,显效86例,有效28例,无效6例,总有效率为95%.结论 长期小剂量米非司酮在治疗子宫肌瘤方面效果显著,能够有效地缩小子宫肌瘤,安全性高,在随访过程中患者病情尚无复发,是现阶段保守治疗子宫肌瘤的理想方式,值得在临床过程中推广应用.
Obserbation on the effect of the long-term low-dose mifepristone on the treatment of hysteromyoma
Objective To observe the effect of the long-term low-dose mifepristone on the treatment of hysteromyoma.Methods From March 2016 to December 2016 in Haiyan maternal and child health-care center,120 cases with hysteromyoma were selected as the object study and were given long term oral low-dose mifepristone.The uterus size, follicle stimulating hormone, myoma size, luteinizing hormone, estrogen and endometrium were observed Results after treatment, the patients with uterine fibroids situation improved markedly, and appeared amenorrhea.At the same time, in patients with clinical symptoms were improved to a certain extent, six months after a drug follicle-stimulating hormone, luteinizing hormone and estrogen levels significantly decreased, and there is no other significant side effects.In addition, on the analysis of the effectiveness of the treatment,86 cases were markedly improved,28 cases effective,6 cases ineffective, the total effective rate was 95%.Conclusion Long-term low-dose mifepristone has worked well in the treatment of uterine fibroids, can effectively reduce uterine fibroids, high security, in the process of follow-up of patients, no recurrence no satisfaction related data, the result can't reach this Conclusion , the authors modify please.Is the ideal way of conservative treatment of uterine fibroids, and is worth popularizing in the process of clinical application.

mifepristonehysteromyomafollicle-stimulating hormoneestrogen progesterone

杨叶莉、王永英

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浙江海盐县妇幼保健院 妇科,浙江 嘉兴 314300

米非司酮 子宫肌瘤 卵泡刺激素 雌激素 孕酮

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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