首页|B型钠尿肽水平在重型肾综合征出血热患者行连续性肾脏替代治疗的应用价值研究

B型钠尿肽水平在重型肾综合征出血热患者行连续性肾脏替代治疗的应用价值研究

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目的 观察和探讨B型钠尿肽(brain natriuretic peptide,BNP)水平对重型肾综合征出血热患者行连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)的应用价值.方法 选取2015年1月~2016年10月收治的48例重型肾综合征出血热患者为研究对象.保守治疗3 d后好转者入选对照组(24例),无好转者继续行CRRT(CRRT组, 24例).记录2组患者保守治疗前平均动脉压(mean arterial pressure,MAP)、清蛋白(albumin,Alb)、血红蛋白(hemoglobin,haemoglobinHb)、B型钠尿肽(BNP)及第1个24 h尿量(24 h尿量);记录保守治疗3 d后尿素氮、血肌酐、BNP及24 h尿量(24 h尿量).比较2组上述临床指标间的差异.结果 对照组与CRRT组Alb、尿素氮、血肌酐、BNP-Ⅰ、BNP-Ⅱ、24 h尿量-Ⅰ、24 h尿量-Ⅱ比较,差异均有统计学意义(P<0.05).结论 经短期保守治疗后的24 h尿量与BNP水平可以较好地预测重型肾综合征出血热患者是否应该行CRRT.
Analysis on the application value of brain natriuretic peptide levels in patients with hemorrhagic fever of seriously renal syndromes continuous renal replacement therapy
Objective To observe and investigate b-type natriuretic peptide(BNP)levels in patients with hemorrhagic fever of seriously renal syndromes line of continuous renal replacement therapy(CRRT)application value.Methods From January 2015 to October 2015 were 48 cases of patients with hemorrhagic fever of seriously renal syndromes as the research object.Conservative treatment after 3 d better person to be included in the control group(24cases), no better continue CRRT(CRRT group, 24cases).Records in the two groups before the conservative treatment in patients with mean arterial pressure(MAP), albumin(propagated), hemoglobin(Hb), b-type natriuretic peptide(BNP)and a 24 h urine(24 h urine);Record after conservative treatment 3 d urea nitrogen, serum creatinine, BNP and 24 h urine(24 h urine).Compare the differences between the two groups of the clinical indicators.Results The control group with CRRT group propagated, urea nitrogen, serum creatinine, BNP-I, BNP-Ⅱ, 24 h urine-Ⅰ, 24 h urine-Ⅱ comparison, the difference had statistical significance (P<0.05).Conclusion The short term the 24 h urine after conservative treatment and BNP levels can better predict whether patients with hemorrhagic fever of Seriously renal syndromes should be line of CRRT.

B-type natriuretic peptideseriously renal syndromes typehemorrhagic feverCRRT

张瑞娟、赵文轩

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陕西省咸阳市中心医院 传染科,陕西 咸阳 712000

B型钠尿肽 重型肾综合征 出血热 CRRT

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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