首页|血清透明质酸、层粘连蛋白对冠心病患者并发心肌梗死的诊断意义

血清透明质酸、层粘连蛋白对冠心病患者并发心肌梗死的诊断意义

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目的 旨在探讨血清透明质酸和层粘连蛋白对冠心病患者并发心肌梗死的诊断意义.方法 选取本院心内科于2015年7月~2016年7月收治的非心肌梗死冠心病患者100例作为冠心病组,同期选择冠心病合并心肌梗死患者100例作为梗死组.对比2组患者血清透明质酸和层粘连蛋白表达,分析清透明质酸和层粘连蛋白表与血脂及血糖指标表达.结果 梗死组血清LN和HA表达均显著高于冠心病组(P<0.01).2组患者血清LN和HA表达均呈现,三支病变>双支病变>单支病变(P<0.05),梗死组不同冠状动脉病变患者LN和HA表达均显著高于冠心病组患者(P<0.05).前壁复合下壁梗死患者LN表达及HA表达显著高于前壁区梗死和下壁区梗死患者(P<0.05).结论 冠心病患者血清HA、LN表达持续升高可能诱发急性心肌梗死.
Diagnostic value of serum hyaluronic acid and laminin in patients with coronary heart disease complicated with myocardial infarction
Objective To investigate the diagnostic value of serum hyaluronic acid and laminin in patients with coronary heart disease complicated with myocardial infarction.Methods 100 patients with coronary heart disease(CHD) were selected as the coronary heart disease group, and the patients with CHD and myocardial infarction(AMI) were selected as the infarct group in our hospital from July 2015 to July 2016.The levels of serum hyaluronic acid and laminin were compared between the two groups, and the levels of hyaluronic acid and laminin were analyzed.Results The expression of LN and HA in the infarction group were significantly higher than those in the coronary heart disease group(P<0.01).LN and HA expression were presented in the two groups, Coronary artery three ressel disease>double branch lesions > single vessel disease(P<0.05).LN and HA expression in different coronary artery lesions in the infarction group were significantly higher than those in the coronary heart disease group(P<0.05).The expression of LN and HA in patients with anterior and inferior wall myocardial infarction were significantly higher than those in anterior wall and inferior wall infarction(P<0.05).Conclusion The increase of serum HA and LN in patients with coronary heart disease may cause acute myocardial infarction.

serum hyaluronic acidlaminincoronary heart diseasemyocardial infarction

刘梦平、刘宝奇

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西安交通大学第一附属医院 心内科,陕西 西安 710061

榆林市府谷县人民医院 心内科,陕西 榆林 719400

血清透明质酸 层粘连蛋白 冠心病 心肌梗死

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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