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抗菌药物联合用药现状调查与研究

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目的 调查研究抗菌药物联合用药现状,提高抗菌药物用药合理性.方法 选择2015年2月~2016年5月本院门诊以及急诊抗菌药物处方1734张,结合《药理学》、《临床用药须知》以及药品说明书对这些处方进行统计分析,研究抗菌药名称,联合用药方式、类型、疗程、合理性等方面情况.结果 使用抗菌素处方占总处方量45.44%,其中抗菌药物联合用药76.65%,以注射剂型和注射剂型联合形式最多41.72%;口服剂型和口服剂型联合用药21.19%.联合青霉素用药比例最高43.54%,之后是头孢类27.81%.合理配伍处方86.92%,处方配伍不合理13.08%.在不合理配伍处方中,大部分为药效学配伍禁忌82.28%.结论 当前本院抗菌素药物使用情况逐渐趋于规范化,在临床治疗过程中,了解和掌握药物联合用药适应证,可以显著提高治疗效果,避免不良反应现象的出现,使用药安全性得到有效保证.
Investigation and study on the current situation of combined use of antimicrobial drugs
Objective To investigate the present situation of the combination of antimicrobial drugs and to improve the rationality of antimicrobial medication.Methods Choose 1734 prescription of antimicrobial from February 2015 to May 2016 in our hospital outpatient service and emergency departments, combined with "pharmacology", "clinical medication instructions" and drug instruction,the prescriptions were analyzed statistically,and the name of antimicrobials, combination mode, type, period of treatment, rationality and other aspects of the situation were studied.Results The total prescription of antibiotics was 45.44%, and the combination of antimicrobial drugs was 76.65 %, with the combination form of the dosage form and the injection machine with a maximum of 41.72%.Oral dosage form and oral dosage form combined drug 21.19%.The proportion of combined penicillin was 43.54 percent, followed by the cephalospora 27.81%.The rational compatibility prescription 86.92%, the prescription compatibility is unreasonable 13.08%.In the unreasonable preparation of the prescription, the majority of the formulations for pharmacodynamics were 82.28%.Conclusion The current use of antibiotics in our hospital gradually become standardized, in the process of clinical treatment, to understanded and master the drug combination medication indications, can significantly improve the treatment effect, to avoid the occurrence of adverse reaction phenomenon, the use of drug safety is effectively guaranteed.

antimicrobial agentscombined use of drugspresent situationinvestigation

黄丽君、郑丽贞

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苍南县妇幼保健院 药房,浙江 温州 325800

苍南县中医院 中药房,浙江 温州 325800

抗菌药物 联合用药 现状 调查

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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