首页|宫颈渗液细胞游离亚铁原卟啉检测在宫颈癌筛查中的价值

宫颈渗液细胞游离亚铁原卟啉检测在宫颈癌筛查中的价值

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目的 探讨宫颈渗液细胞游离亚铁原卟啉(Cells Free Ferrous Protoporphyrin,FH)检测在宫颈癌筛查中的应用价值.方法 回顾性分析2013年12月~2014年12月在宁夏中卫市人民医院接受宫颈癌筛查的368例女性的临床资料,分为宫颈正常组(n=210),宫颈癌前病变组(n=130)、宫颈癌组(n=28).均对其进行液基薄层细胞检测(TCT)和FH检测,观察2种检测方法的检测效果,并进行比较.结果 经统计和比较,在对正常宫颈进行检测时,FH检测的假阳性率为19.05%,显著高于TCT检测的4.76%(P<0.05);在对宫颈癌前病变进行检测时,FH检测的检出率为86.15%,低于TCT检测的86.92%,且随着宫颈病变程度的不断提高,2种检测方法的阳性率均呈现出不断上升的情况;在对宫颈癌进行检测时,FH检测的阳性率为96.43%,高于TCT检测的92.86%,但经比较差异无统计学意义.结论 与液基薄层细胞检测(TCT)比较,FH检测在对正常宫颈的检测效果相对较差,但在宫颈癌前病变与宫颈癌检测方面与TCT检测基本一致,因此,FH检测在宫颈癌筛查中仍然具有一定的应用价值.
The value of detection of free zinc protoporphyrin in cervical infiltration cells in cervical cancer screening
Objective To investigate the value of Cells Free Ferrous Protoporphyrin (FH) detection in cervical cancer screening.Methods Retrospective analysis of December 2013 to 2014 year in December to accept the clinical data of 368 cases of female cervical cancer screening in Ningxia People's Hospital of Zhongwei Prefecture, divided into normal group (n=210), cervical precancerous lesions group (n=130) and cervical carcinoma group (n=28).The liquid based thin-layer cell detection (TCT) and FH detection were carried out, and the detection effects of the 2 detection methods were observed and compared.Results The statistics and comparison, in the detection of normal cervix, the false positive rate of FH detection was 19.05%, significantly higher than the detection of TCT 4.76% (P< 0.05);in the detection of cervical precancerous lesions, FH positive detection rate was 86.15%, lower than the detection of TCT 86.92%, and with the degree of cervical lesions continuously improve the positive rate of the 2 detection methods are showing a rising situation;in the detection of cervical cancer, the positive rate of FH detection was 96.43%, higher than the detection of TCT 92.86%, but the difference was not significant.Conclusion With ThinPrep cytology test (TCT), FH in the detection of relative detection effect of normal cervix of the poor, but in precancerous lesions and cervical cancer detection and detection of TCT are basically the same, therefore, FH still has a certain application value in screening of cervical cancer.

cervical infiltrationfree cell protoporphyrincervical cancer screeningvalue

杨平安、王茹娟

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宁夏中卫市人民医院 检验科,宁夏 中卫 755000

宫颈渗液细胞游离亚铁原卟啉 宫颈癌筛查 价值

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.(7)
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