中国生化药物杂志2017,Issue(7) :429-430,433.DOI:10.3969/j.issn.1005-1678.2017.07.176

腹腔镜子宫肌瘤剥除术对子宫肌瘤患者疗效及术后康复的影响

Effect of laparoscopic myomectomy on the changes of T cell subsets in patients with uterine fibroids

王凤彦 王娟 李万胜 郭辉 姜蓓蓓 王慧筠 刘玉欣
中国生化药物杂志2017,Issue(7) :429-430,433.DOI:10.3969/j.issn.1005-1678.2017.07.176

腹腔镜子宫肌瘤剥除术对子宫肌瘤患者疗效及术后康复的影响

Effect of laparoscopic myomectomy on the changes of T cell subsets in patients with uterine fibroids

王凤彦 1王娟 2李万胜 2郭辉 2姜蓓蓓 2王慧筠 3刘玉欣4
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作者信息

  • 1. 保定市徐水区人民医院 妇科,河北 保定 072550
  • 2. 河北医科大学第四医院 妇科,河北 石家庄 050011
  • 3. 保定市骨科医院 防保科,河北 保定 017000
  • 4. 保定市顺平县东方医院 妇科,河北 保定 072250
  • 折叠

摘要

目的 腹腔镜子宫肌瘤剥除术对子宫肌瘤(UM)患者疗效及术后康复的影响.方法 选取保定市徐水区人民医院84例UM患者,依据术式不同分组,观察组43例采取腹腔镜子宫肌瘤剥除术治疗,对照组41例采取开腹子宫肌瘤剥除术治疗.对比2组手术情况、术后恢复情况、并发症发生情况及术后12个月复发情况.结果 观察组肛门首次排气时间、住院时间均较对照组缩短,术中出血量、术后疼痛评分(VAS)均较对照组降低,差异有统计学意义(P<0.05);观察组术后并发症发生率6.98%(3/43)低于对照组26.83%(11/41),且经随访,术后12个月观察组复发率2.33%(1/43)低于对照组19.51%(8/41),差异有统计学意义(P<0.05).结论 采用腹腔镜子宫肌瘤剥除术治疗子宫肌瘤疗效显著,可降低术后并发症发生率及复发率,促进患者康复.

Abstract

Objective To study the effect of laparoscopic myomectomy on the curative effect and postoperative rehabilitation of patients with uterine fibroids (UM).Methods From March 2014 to March 2016, selected 84 patients with UM in the people's hospital of Baoding Xushui district were divided into observation group (n=43) and control group(n=41) according to the different operation procedures, the observation group were treated with laparoscopic myomectomy and the control group were treated with open uterine fibroids.Serum T cell subsets (CD4+, CD8+, CD4+/ CD8+) between the two groups before and 1 day after operation were compared, and CA125, Cor, IL-1β levels, and surgery condition, postoperative recovery, complicationsand postoperative 12 months of recurrence were statistically compared.Results The serum CD4+, CD8+, CD4+/CD8+ levels in the observation group were significantly higher than those in the control group at 1 day after operation, the difference was statistically significant (P<0.05);the first exhaust time and hospitalization of the observation group were significantly shorter than those of the control group, and the intraoperative blood loss and postoperative pain score (VAS) were significantly lower than those in the control group (P<0.05);The incidence of postoperative complications in the observation group (6.98%, 3/43) was significantly lower than that in the control group (26.83%, 11/41), by follow-up, the recurrence rate (2.33%, 1/43) was lower than that of the control group (19.51%, 8/41), the difference was statistically significant (P<0.05).Conclusion Treatment of uterinemyoma using laparoscopic myomectomy gets a significant effect, and the body inflammation, stress response lighter and the effect of immune function is small, which can reduce the postoperative complications and recurrence rate and promote the rehabilitation of patients, and less impact on immune function.

关键词

子宫肌瘤/腹腔镜子宫肌瘤剥除术/术后康复

Key words

uterinemyoma/laparoscopic uterine fibroidectomy/tcell subsets

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出版年

2017
中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
被引量25
参考文献量9
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