地塞米松对ICH实验大鼠血肿脑组织APQ-4及细胞因子表达的影响分析
Effect of dexamethasone on the expression of ICH and APQ-4 in brain tissue of hematoma in rats
王玮 1黄宜宾 1赵方允2
作者信息
- 1. 天津市第五中心医院 药剂科,天津 300450
- 2. 昆明市第一人民医院药剂科,云南 昆明 650011
- 折叠
摘要
目的 探讨地塞米松对ICH实验大鼠血肿脑组织APQ-4、及细胞因子表达的影响.方法 治疗组采取注射1 mg/kg地塞米松进行治疗,模型组和假手术组采取等量生理盐水注射.结果 模型组APQ-4、TNF-ɑ阳性细胞所占比例在术后第2、3、7天最高,假手术组最低(P<0.05).结论 地塞米松有利于减轻ICH大鼠脑组织中APQ-4的表达情况,同时减低TNF-ɑ表达.
Abstract
Objective To investigate the effect of dexamethasone on the expression of APQ-4 and cytokines in the hematoma and brain tissue of ICH rats. Methods The treatment group was treated with injection of 1mg/kg and dexamethasone, and the model group and the sham operation group were injected with the same amount of normal saline. Results The model group APQ-4, TNF- positive cells. The proportion of second, third, the highest in the 7d after the operation, the sham operation group was the lowest (P<0.05). Conclusion Dexamethasone is beneficial to reduce the APQ-4 expression in brain tissue of rats in ICH, while reducing the expression of TNF- alpha.
关键词
地塞米松/脑出血/水通道蛋白-4/肿瘤坏死因子-ɑKey words
dexamethasone/cerebral hemorrhage/aquaporin-4/tumor necrosis factor-ɑ引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据