生姜配伍大黄抗高尿酸血症实验研究

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中文摘要：目的观察生姜配伍大黄对高尿酸血症模型小鼠的影响.方法采用酵母膏灌胃造模的方法建立高尿酸血症模型小鼠,实验设生姜配伍大黄提取物低中高剂量组、大黄提取物组、别嘌呤醇组、空白对照组、模型组,用试剂盒法测定血清中尿酸(uA)、肌酐(Cr)和尿素氮(BUN)水平以及肝中黄嘌呤氧化酶的活性.结果与模型组比较,生姜配伍大黄高、中、低剂量组小鼠尿酸水平和肝脏XOD活性呈现剂量依赖性下降.结论生姜配伍大黄具有较强的降尿酸及抑制黄嘌呤氧化酶活性的作用.

外文标题：The effects of Ginger combined with Rhubarb on hyperuricemia in mice

外文摘要：Objective This study was aimed to investigate the effects of Ginger combined with Rhubarb on hyperuricemia in mice. Methods The mice hyperuricemic model was made by orally administering yeast extract, The mice were randomly divided into 7 groups,includinglow,middle and high dose of Ginger combined with Rhubarb group, Rhubarb group, and allopurinol group was given corresponding drugs respectively by gavage, and the uric acid (uA), creatinine (Cr), urea nitrogen (BUN) level in blood and XOD activity in liver were observed for all mice in each group. Results Compared to hyperuricaemia model control group,UA level and XOD activity in liver of mice of the three doses of Ginger combined with Rhubarb groups received dose-dependent decrease. Conclusion Ginger combined with Rhubarb can reduce UA level and XOD activity in liver in hyperuricaemia mice model.

外文关键词：

gingerrhubarbcompatibilityhyperuricemia

作者：

周杰芳、范海珠

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作者单位：

浙江省中医院,浙江杭州 310006

关键词：

生姜大黄配伍高尿酸血症

出版年：

2017

DOI：