缬沙坦和左旋氨氯地平联用对老年高血压患者尿微量清蛋白的影响
Effects of valsartan and amlodipine on urinary microalbumin in elderly patients with hypertension
宋建敏 1韩胜利 1龚雪1
作者信息
- 1. 北京市西城区展览路医院 药剂科,北京 100044
- 折叠
摘要
目的 研究分析缬沙坦和左旋氨氯地平联用对老年高血压患者尿微量清蛋白的影响.方法 选取本院2015年5月~2016年10月收治的100例老年高血压患者为研究对象,随机分为对照组和实验组,每组50例.对照组患者给予口服缬沙坦治疗,实验组患者给予缬沙坦和左旋氨氯地平联用.2组患者的治疗时间均为12周.比较分析2组患者的相关临床指标.结果 治疗后,2组患者均无出现明显的不良反应.实验组患者发生2例头痛,1例患者眩晕,对照组患者2例患者出现眩晕,2组患者不良反应发生率比较差异无有统计学意义.实验组患者降压作用显著高于对照组,差异具有统计学意义(P<0.05).治疗后,2组患者尿微量清蛋白显著低于治疗前,实验组尿微量清蛋白下降程度优于对照组,差异具有统计学意义(P<0.05).结论 缬沙坦和左旋氨氯地平联用治疗老年高血压患者临床效果较好,降压作用更强,能够显著改善患者的尿微量清蛋白,具有临床进一步推广和应用的意义.
Abstract
Objective To investigate the effect of valsartan and amlodipine on urinary microalbumin in elderly hypertensive patients. Methods 100 elderly patients with hypertension treated in our hospital from May 2015 to October 2016 were selected and randomly divided into the control group and the experimental group, with 50 patients in each group. The patients in the control group received oral valsartan, and the patients in the experimental group were treated with valsartan and amlodipine. The treatment time of the experimental group and the control group was 12 weeks. The clinical indexes of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, the experimental group and the control group did not have obvious adverse reactions. There were 2 cases of headache in the experimental group, 1 cases of vertigo, and 2 cases of vertigo in the control group. However, there was no significant difference in the incidence of adverse reactions between the experimental group and the control group, and there was no statistical significance. The antihypertensive effect of the experimental group was significantly higher than that of the control group, with statistical significance (P<0.05). After treatment, the urinary microalbumin in the experimental group and the control group was significantly lower than that in the treatment group, and the level of microalbuminuria in the experimental group was lower than that in the control group, with statistical significance (P<0.05). Conclusion The clinical effect of treatment of elderly patients with hypertension better combined with valsartan and amlodipine, antihypertensive effect is stronger, can significantly improve the patient's urinary albumin, with further clinical promotion and application significance.
关键词
缬沙坦/左旋氨氯地平/老年高血压/尿微量清蛋白/临床影响Key words
stan/amlodipine/elderly hypertension/microalbuminuria/clinical impact引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据