首页|外固定架结合抗菌素硫酸钙治疗术后感染性骨不连

外固定架结合抗菌素硫酸钙治疗术后感染性骨不连

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目的 探讨一期清创后用外固定架结合抗菌素硫酸钙填塞骨髓腔、VSD持续负压引流、局部皮瓣转移等技术治疗术后感染性骨不连的临床疗效.方法 选取2012年8月~2014年8月收治20例创伤性骨髓炎,将自制抗生素硫酸钙置入病灶区,小的骨缺损一期植骨,大的骨缺损行截骨延长.有皮肤缺损的用转移皮瓣修复创面,有部分皮瓣坏死或伤口不愈合者用VSD持续负压引流到肉芽组织新鲜后植皮.结果 12例伤口一期愈合,2例伤口二期愈合,4例局部皮瓣转移后全部成活,2例皮瓣转移后部分坏死,二期植皮后伤口愈合.11例外固定架原位固定,7例行截骨延长治疗的骨折端愈合良好,2例截骨延长会师处延迟愈合,经植骨后最终愈合.所有20例患者术后进行6~32个月,平均(19.2±3.6)个月随访,植皮全部成活,感染得到控制,无复发.骨折愈合时间4~12个月,平均(8.3±2.5)个月.未发现针道感染、骨质疏松、骨折畸形愈合等.但有1例膝关节和2例踝关节僵硬.结论 一期清创后用外固定架固定,采用抗生素硫酸钙填塞骨髓腔和骨折端,小的骨缺损一期植骨,大的骨缺损行截骨延长.一期转移皮瓣修复缺损的创面,有部分皮瓣坏死或伤口不愈合者用VSD持续负压引流到肉芽组织新鲜后植皮,再结合全身使用敏感抗生素,在治疗术后感染性骨不连方面取得了明显的临床效果,缩短了治疗周期,减少了并发症发生率.
External fixator combined antibiotic-calcium sulfate for the treatment of postoperative infected nonunion
Objectives To explore the clinical effect of external fixator combined antibiotic-calcium sulfate packing medullary cavity, VSD continuous drain with negative pressure and local skin flap transposition for the treatment of postoperative infected nonunion after initial debridement. Methods 20 cases of traumatic osteomyelitis from August 2012 to August 2014 were selected and taken antibiotic-calcium sulfate to focal zone. The patients were taken first-stage bone grafting for small bone defects and osteotomy for lengthening for big bone defects. For patients with cutaneous injury, local skin flap transposition was taken. For other patients with partial flap necrosis and non healing wounds, VSD continuous drain with negative pressure was taken. Results Operative incisions of 12 cases were primary healing, two cases were healing by second intention, four cases of flap were survived after local skin flap transposition, and two cases of flap were partial necrosis and healed by second intention. 11 cases of immobilization with external fixator, bone healing was satisfactory in seven cases after osteotomy for lengthening and two cases of bone delayed union in osteotomy for lengthening and recovered after bone transplantation. All patients were followed up for average 19(6-32) months with permatoplasty survived; all the infection of wounds was controlled and relapse-free. The fracture healing period was eight(4-12) month without pin site infection, osteoporosis and deformed healing. But there were 1 cases of knee stiffness and two cases stiffness of ankle joint. Conclusion After initial debridement, taken external fixator and taken antibiotic-calcium sulfate to medullary cavity and fracture ends. The patients were taken first-stage bone grafting for small bone defects and osteotomy for lengthening for big bone defects. For the skin defect after local flap grafting, taken VSD continuous drain with negative pressure for partial necrosis of flap occurred and non healing wounds cases. The method obtained prominent curative effect, reduces the treatment cycle and reduce the complications in the treatment of postoperative infected nonunion.

antibiotic- calcium sulfateflap transferosteotomy lengtheningtraumatic osteomyelitis

赵潼宝、王明

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陕西省潼关县人民医院 骨科,陕西 渭南 714300

抗生素硫酸钙 转移皮瓣 截骨延长 创伤性骨髓炎

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(8)
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