含洛铂化疗方案经肝动脉化疗栓塞术治疗原发性肝癌的疗效及安全性
Efficacy and safety of transarterial chemoembolization with chemotherapy regimen containing platinum in the treatment of primary liver cancer
饶文 1叶锐剑 2林桂华3
作者信息
- 1. 四川江油市九0三医院 消化内科,四川 江油 621700
- 2. 四川江油市九0三医院 肿瘤科,四川 江油 621700
- 3. 四川江油市九0三医院 疼痛科,四川 江油 621700
- 折叠
摘要
目的 分析含洛铂化疗方案经肝动脉化疗栓塞术(TACE)治疗原发性肝癌的疗效及安全性.方法 选取本院2015年12月~2016年12月收治的86名中晚期原发性肝癌患者,随机分为2组,各43例.研究组联合应用洛铂、盐酸表柔比星、丝裂霉素进行碘油化疗,对照组联合应用奥沙利铂、盐酸表柔比星、丝裂霉素进行碘油化疗,2组均用明胶海绵阻断肿瘤供血血管,连续2个疗程.按照实体瘤疗效评价标准(RECIST)评价疗效,同时比较2组患者不良反应发生情况.结果 2组总有效率无明显差异,研究组显效率(20.93%)明显高于对照组(6.98%),差异有统计学意义(P<0.05);术后不良反应中,研究组血液学毒性发生率(30.23%)略高于对照组(20.93%),胃肠道反应(44.19%)与肝肾损害发生率(13.95%)均依次低于对照组的60.47%、25.58%,但差异无统计学意义(P>0.05);研究组神经毒性发生率(2.33%)明显低于对照组(27.91%),差异有统计学意义(P<0.05).结论 对中晚期原发性肝癌患者,含洛铂化疗方案经肝动脉化疗栓塞术与含奥沙利铂化疗方案的疗效无明显差别,不良发应发生情况也相似,但洛铂的神经毒性发生率低.
Abstract
Objective To analyze the efficacy and safety of transarterial chemoembolization (TACE) with chemotherapy regimen containing platinum in the treatment of primary liver cancer. Methods 86 patients with advanced hepatocellular carcinoma treated in our hospital from December 2015 to December 2016 were selected and randomly divided into two groups with 43 cases each group. Lipiodol chemotherapy was performed with Lobaplatin, epirubicin hydrochloride and mitomycin in the study group, control group while Lipiodol chemotherapy was performed with oxaliplatin, epirubicin hydrochloride and mitomycin in the control group. The gelatin sponge was used to block tumor blood vessels and the treatment lasted for 2 courses. According to the curative effect evaluation standard of solid tumor (RECIST), the curative effect was evaluated and the adverse reactions were compared between the two groups. Results The total effective rates of the two groups were not significantly different , but the effective rate of the study group (20.93%) was significantly higher than that of the control group (6.98%), and the difference was statistically significant (P<0.05). The incidence of hematologic toxicity in the study group (30.23%) was slightly higher than that in the control group (20.93%), the incidence of gastrointestinal reactions (44.19%) and liver and kidney damage (13.95%) were lower than that of the control group respectively by 60.47% and 25.58%, but there was no significant difference . The incidence of neurotoxicity in the study group (2.33%) was significantly lower than that in the control group (27.91%), and the difference was statistically significant (P<0.05). Conclusion For patients with advanced hepatocellular carcinoma, there was no significant difference between the efficacy and safety of transarterial chemoembolization with chemotherapy regimen containing platinum and oxaliplatin chemotherapy regimen, and adverse reactions are similar, but the incidence of neurotoxicity is low.
关键词
含洛铂化疗方案/经肝动脉化疗栓塞术/原发性肝癌/疗效/安全性Key words
chemotherapy regimen containing platinum/transarterial chemoembolization/primary hepatocellular carcinoma/efficacy/safety引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据