恩替卡韦分散片治疗失代偿期乙肝肝硬化的临床疗效
Analysis on the effect of entecavir dispersible tablets on the treatment of patients with decompensated hepatitis B cirrhosis
卢胜家 1刘长灵 1邵婷婷1
作者信息
- 1. 浙江省立同德医院 感染科,浙江 杭州 310012
- 折叠
摘要
目的 研究恩替卡韦分散片治疗失代偿期乙肝肝硬化的临床疗效.方法 选取浙江省立同德医院2014年2月~2016年9月收治的100例失代偿期乙肝肝硬化患者,随机分为对照组和试验组,每组患者各为50例.对照组患者进行常规的治疗,试验组患者在常规治疗上给予恩替卡韦分散片治疗.比较分析试验组与对照组患者的治疗效果.结果 试验组有效率为92.0%,对照组有效率为70.0%,试验组治疗有效率显著高于对照组,差异具有统计学意义(P<0.05).试验组Child-pugh评分为(6.12±1.43)分,对照组为(7.23±1.95)分,对照组评分显著高于试验组,差异具有统计学意义(P<0.05).试验组患者的HBeAg阴转率为22.0%,HBV-DNA阴转率为86.0%,显著高于对照组,差异有统计学意义(P<0.05).结论 恩替卡韦分散片治疗失代偿期乙肝肝硬化临床效果较好,能够在很大程度上提高治疗有效率,恢复患者肝功能,具有临床进一步推广和应用的意义.
Abstract
Objective To study and analyze of entecavir dispersible tablets on the treatment of patients with decompensated hepatitis B cirrhosis. Methods From February 2014 to September 2016, 100 patients with decompensated hepatitis B cirrhosis were randomly divided into the control group and the experimental group, 50 patients in each group. The control group were received routine treatment, while the experimental group were received entecavir dispersible tablets treatment on the basis of conventional treatment. The therapeutic effects in the two groups were compared and analyzed. Results The effective rate in the experimental group was 92.0%, and 70.0% in the control group. The effective rate in the experimental group was significantly higher than that in the control group, the difference has statistically significant (P<0.05). The Child-pugh score in the experimental group was (6.12±1.43) points, and the score in the control group was (7.23±1.95) points. The score in the control group was significantly higher than that in the experimental group, with statistical difference (P<0.05). The negative rate of HBeAg in the experimental group was 22.0%, while 86% in the control group the difference has statistically significant (P<0.05). Conclusion The clinical effect is better which entecavir dispersible tablets is used in the treatment of the patients with decompensated hepatitis B cirrhosis, which can improve the treatment efficiency to a great extent, recover the liver function, has the further promotion and application significance.
关键词
恩替卡韦分散片/失代偿期/乙肝肝硬化Key words
entecavir dispersible tablets/decompensation/hepatitis B cirrhosis引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据