喘息患儿与血清25-羟维生素D3水平间相关性分析
Correlation between wheezing and serum 25-hydroxy vitamin D3 levels
顾红丹 1郭素娟 1林丽 1李杰 1赵怡莎1
作者信息
- 1. 温岭市妇幼保健院 儿科,浙江 温岭 317500
- 折叠
摘要
目的 探讨喘息患儿与血清25-羟维生素D3水平间相关性.方法 选取温岭市妇幼保健院收治的130例下呼吸道感染患儿作为研究对象,其中喘息患儿为甲组(n=70);普通肺炎(无喘息)者为乙组(n=60);另选取同期于医院健康体检的健康儿童为对照组(n=60).采用ELISA方法测定对照组及住院患儿入院当日血清25-羟维生素D3水平;同时检测甲乙2组患儿病原学及过敏原.结果 甲组、乙组血清25-羟维生素D3水平分别为(56.92±16.88)nmol/L、(70.68±21.96)nmol/L,明显低于对照组(82.69±17.63)nmol/L,(t=8.50,3.30;P=0.00,0.00);甲乙组比较(t=3.85,P=0.00).甲组病毒检测阳性率为65.71%,明显高于乙组(35.00%,χ2=12.20,P=0.00).甲组过敏原检查阳性率30.00%与对照组(35.00%)比较(χ2=0.36,P=0.54).甲组患儿血清25-羟维生素D3水平<75 nmol/L率为88.57%,明显高于乙组(60.00%,χ2=14.21,P=0.00).血清25-羟维生素D3水平<75 nmol/L的98例患儿中,其病毒检测阳性率为57.14%,明显高于血清25-羟维生素D3水平≥75 nmol/L患儿病毒检测阳性率(18.75%,χ2=14.25,P=0.00).血清25-羟维生素D3水平<75 nmol/L患者中过敏原阳性率35.71%,明显高于血清25-羟维生素D3水平≥75 nmol/L患儿过敏原阳性率(21.88%,χ2=2.11,P=0.14).结论 喘息患儿的主要发病因素为病毒感染,而患儿血清25-羟维生素D3水平较低则会增加其病毒感染风险,从而致患者喘息发病风险增加,因此临床可通过检测儿童血清25-羟维生素D3水平来预测和干预儿童喘息的发生.
Abstract
Objective To investigate the relationship between wheezing and serum levels of 25-hydroxyvitamin D3.Methods 130 children with lower respiratory tract infection were selected as the subjects, the children with wheezing in group A([Abstract] Objective To investigate the relationship between wheezing and serum levels of 25-hydroxyvitamin D3.Methods 130 children with lower respiratory tract infection were selected as the subjects, the children with wheezing in group A(n=70),normal pneumonia (no wheezing) were group B(n=60); The healthy children who were examined in the hospital at the same period were selected as the control group (n=60). The serum levels of 25-hydroxyvitamin D3 were measured by ELISA in the control and hospitalized children. The pathogens and allergens of the two groups were also detected. Results The levels of serum 25-hydroxyvitamin D3 in group A and group B were (56.92±16.88) nmol/L, (70.68±21.96) nmol/L, respectively, which was significantly lower than that in control group (82.69±17.63) nmol/L, ( t=8.50, 3.30,P=0.00,0.00); compared with group A( t=3.85, P=0.00). The positive rate of group A was 65.71%, which was significantly higher than that of group B (35.00%, χ2=12.20,P=0.00). The positive rate of group A was 30.00% compared with the control group (35.00%, χ2=0.36,P=0.54). The serum level of 25-hydroxyvitamin D3 was 75.57% in group A, which was significantly higher than that in group B (60.00%,χ2=14.21, P=0.00). The positive rate of virus detection was 57.14% in 98 children with serum 25-hydroxy vitamin D3 level<75 nmol/L, which was significantly higher than that in serum 25-hydroxy vitamin D3 level≥75 nmol/L(18.75%, χ2=14.25, P=0.00). The positive rate of allergens in serum 25-hydroxy vitamin D3 level <75 nmol/L was 35.71%, which was significantly higher than that in serum 25-hydroxy vitamin D3 level≥75 nmol/L(21.88%, χ2=2.11, P=0.14). Conclusion The main risk factor for children with wheezing is viral infection, while the low level of serum 25-hydroxy vitamin D3 in children increases the risk of viral infection, resulting in increased risk of wheezing in patients,so the clinical can occur through the detection of serum 25- hydroxyvitamin D3 levels to predict and intervention for children with wheezing.
关键词
血清25-羟维生素D3/喘息/病毒感染/肺炎/过敏原Key words
Serum 25-hydroxyvitamin D3/wheezing/viral infection/pneumonia/allergens引用本文复制引用
基金项目
2014年温岭市科技计划项目(2014C311082)
出版年
2017
NETL
NSTL
万方数据