首页|白蛋白结合型紫杉醇治疗晚期宫颈癌的疗效与安全性探讨

白蛋白结合型紫杉醇治疗晚期宫颈癌的疗效与安全性探讨

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目的 探讨白蛋白结合型紫杉醇对晚期宫颈癌患者的临床疗效及安全性,为临床治疗提供参考.方法 选择武汉科技大学附属天佑医院收治的晚期宫颈癌患者47例为观察对象,收治时间为2015年5月~2017年1月,采用电脑随机分组方式将其分成对照组与实验组,对照组23例晚期宫颈癌患者实施紫杉醇化疗治疗,实验组24例晚期宫颈癌患者实施白蛋白结合型紫杉醇化疗治疗,观察2组晚期宫颈癌患者治疗后瘤体最大直径、症状缓解时间、生活质量评分、近期疗效、不良反应发生率等差异.结果 2组晚期宫颈癌患者在治疗后各项观察指标均存在显著差异,具有统计学意义(P<0.05),其中实验组近期疗效比对照组近期疗效高出31.52%.结论 针对晚期宫颈癌患者实施白蛋白结合型紫杉醇化疗治疗能有效提高患者治疗的疗效,安全性较高,值得临床推广应用.
Efficacy and safety of albumin bound paclitaxel in patients with advanced cervical cancer
Objective To investigate the clinical efficacy and safety of albumin bound paclitaxel in patients with advanced cervical cancer, and to provide reference for clinical practice. Methods The hospital treated 47 cases of advanced cervical cancer patients as the observation object, from May 2015 to January 2017, the computer randomly divided into the control group and the experimental group by computer, the control group of 23 cases of advanced cervical cancer patients from time with paclitaxel chemotherapy, 24 cases of advanced cervical cancer patients were treated with albumin bound paclitaxel chemotherapy, observed patients with advanced cervical cancer after treatment of the two groups the maximum diameter of the tumor, relieve symptoms, efficacy, quality of life score, the incidence of adverse reactions were compared. Results The two groups of patients with advanced cervical cancer after treatment, there are significant differences in the observation index, statistical significance (P<0.05), in which the short-term efficacy of the experimental group is higher than the short-term efficacy of the control group by 31.52%. Conclusion For patients with advanced cervical cancer, the implementation of albumin binding paclitaxel chemotherapy can effectively improve the efficacy of the treatment of patients, high safety, worthy of clinical treatment.

albumin boundpaclitaxeladvancedcervical cancerefficacysafety

瞿秋红、韦立蓓、尹伶

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武汉科技大学附属天佑医院 妇产科,湖北 武汉 430064

白蛋白结合型 紫杉醇 晚期 宫颈癌 疗效 安全性

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(9)
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