首页|六君子汤治疗缓解期过敏性咳嗽对患儿总病程及炎性介质的影响

六君子汤治疗缓解期过敏性咳嗽对患儿总病程及炎性介质的影响

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目的 探讨六君子汤治疗缓解期过敏性咳嗽对患儿总病程及炎性介质的影响.方法 选取北京市密云区中医医院2011年4月~2012年4月收治的86例缓解期过敏性咳嗽患儿,按抽签随机分为观察组与对照组,每组43例,对照组给予基础西药治疗,观察组在对照组的基础上另给予六君子汤治疗.比较2组患儿临床疗效、住院时间、总病程,白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)等炎性细胞因子水平,肺功能及不良反应发生率.结果 观察组疗效总有效率(90.70%)显著高于对照组(72.09%),差异具有统计学意义(P<0.05);观察组住院时间(13.35±3.24)d,总病程(17.68±4.53)d均短于对照组[(16.23±3.10)d、(20.35±4.67)d],差异具有统计学意义(P<0.05).观察组治疗后炎症因子水平和肺功能指标与对照组比较,差异具有统计学意义(P<0.05).2组均未发生不良反应.结论 六君子汤联合基础西药治疗缓解期过敏性咳嗽,可改善炎性细胞因子水平及肺功能,缩短住院时间、总病程,安全性高,具有较好的临床使用价值.
Effect of Liujunzi soup on allergic cough in remission stage and total inflammation of children
Objective To evaluate the effect of Liujunzi soup on the total course of disease and inflammatory mediators in patients with remission of allergic cough. Methods Eighty six patients with allergic cough were enrolled in our hospital from April 2011 to April 2012. The patients were randomly divided into observation group (n = 43) and control group (n = 43). The control group was given basic western medicine treatment, the observation group in the control group on the basis of another treatment of six gentleman soup. The levels of inflammatory cytokines, pulmonary function and adverse reactions were compared between the two groups in clinical efficacy, hospitalization time, total course of disease, IL-2, TNF-α and IL-6. Results The total effective rate was 90.70% in the observation group was significantly higher than that in the control group (72.09%)( P<0.05). The duration of hospitalization (13.35 ± 3.24) d and the total course of disease (17.68 ± 4.53) d were significantly shorter than those in the control group (16.23 ±3.10) d, (20.35 ± 4.67) d (P<0.05). The levels of inflammatory factors and pulmonary function in the observation group were statistically significant compared with the control group (P<0.05). No adverse reactions occurred in both groups. Conclusion Liujunzi Decoction combined with western medicine can improve the level of inflammatory cytokines and lung function, shorten the length of hospital stay, the total course of disease and high safety, and have good clinical value.

Liujunzi soupremission periodallergic coughtotal courseinflammatory mediators

卢敬东、丘婧

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北京市密云区中医医院 儿科,北京 101500

六君子汤 缓解期 过敏性咳嗽 总病程 炎性介质

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(9)
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