甲基强的松龙冲击疗法对急性脊髓损伤患者脊髓神经功能的影响及安全性
Effect and safety of methylprednisolone pulse therapy on spinal nerve function in patients with acute spinal cord injury
姚磊 1王涛1
作者信息
- 1. 江油九零三医院骨一科,四川 江油 621700
- 折叠
摘要
目的 探究甲基强的松龙冲击疗法对急性脊髓损伤(ASCI)患者脊髓神经功能的影响并进行安全性评价.方法 选取2010年1月～2016年12月,本院收治的ASCI患者200例,随机分为2组,各100例.对照组予常规基础治疗,研究组增加甲基强的松龙冲击治疗.以美国脊髓损伤学会评分标准(ASIA)为依据,2组患者均在入院前和治疗6周后进行神经功能恢复情况评分,同时记录不良反应发生情况.结果 2组治疗后感觉和运动功能评分均高于治疗前,差异有统计学意义(P<0.05),且研究组明显高于对照组,组间比较差异有统计学意义(P<0.05);不良反应发生情况,研究组总发生率(25.00％)显著高于对照组(10.00％),差异有统计学意义(P<0.05),且研究组肺部感染和胃肠道反应发生率均明显高于对照组,差异有统计学意义(P<0.05).结论 甲基强的松龙冲击疗法对ASCI患者神经功能恢复效果显著,但不良反应发生率较高,临床中需加强监测和干预.
Abstract
Objective To investigate the effect of methylprednisolone pulse therapy on spinal nerve functions in patients with acute spinal cord injury (ASCI) and evaluate its safety. Methods 200 patients with ASCI treated in our hospital from January 2010 to December 2016 were selected and were randomly divided into two groups,with 100 cases each group. The patients in control group were treated with routine basic treatment while patients in the study group were treated with methylprednisolone pulse therapy. On the basis of the American spinal cord injury Society scoring criteria (ASIA), the neurological functional recovery scores were performed were scored before and 6 weeks after treatment between the two groups and the adverse reactions were recorded. Results The scores of sensory and motor function of the patients in the two groups were higher than those before the treatment and there was statistical difference (P<0.05), and the scores in the study group was significantly higher than those in the control group, and the difference between the two grouPs was statistically significant (P<0.05). The incidence of adverse reactions in the study group (25.00％) was significantly higher than that in the control group (10.00％), and the difference was statistically significant (P<0.05). The incidence of lung infection and gastrointestinal reaction in the study group were significantly higher than those in the control group and there were statistical difference (P<0.05). Conclusion Methylprednisolone pulse therapy has significant effect on the recovery of neurological function in patients with ASCI, but the incidence of adverse reactions is high, so it is necessary to strengthen the monitoring and intervention in clinic.
关键词
甲基强的松龙冲击疗法/急性脊髓损伤/脊髓神经功能/安全性Key words
methylprednisolone pulse therapy/acute spinal cord injury/spinal nerve function/safety引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据