首页|酚妥拉明联合小剂量多巴胺对新生儿坏死性小肠结肠炎患者手术率、疗效及临床不良反应的影响

酚妥拉明联合小剂量多巴胺对新生儿坏死性小肠结肠炎患者手术率、疗效及临床不良反应的影响

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目的 探究酚妥拉明联合小剂量多巴胺对新生儿坏死性小肠结肠炎患者手术率、疗效及不良反应的影响.方法 选取本院2013年1月~2017年1月收治的60例新生儿坏死性小肠结肠炎患儿作为研究对象,并给予随机分组,对照组30例,给予单纯酚妥拉明静滴治疗;干预组30例,在对照组基础上给予小剂量多巴胺治疗,对2组患儿禁食时间、住院时间、手术率、疗效以及不良反应发生情况进行综合评价.结果 干预组患儿平均禁食时间、住院时间均显著低于对照组(P<0.05),有统计学意义;干预组患儿的手术率、治疗总有效率分别为3.3%、93.3%,对照组患儿手术率、治疗总有效率分别为16.7%、70.0%,差异存在统计学意义(P<0.05);且干预组治疗后仅有2例出现不良反应,占6.7%,与对照组的23.3%差异有统计学意义(P<0.05).结论 在酚妥拉明治疗基础上对新生儿坏死性小肠结肠炎患儿给予小剂量多巴胺治疗,能够缩短禁食时间与住院时间,降低中转手术率,且不良反应少,疗效显著,值得临床推广应用.
The effect of the small dose dopamine on the surgical rate, curative effect and adverse effects of neonatal necrotizing enterocolitis
Objective To investigate the effect of the small dose dopamine on the surgical rate, curative effect and adverse reactions of the neonatal necrotic enteritis. Methods From January 2013 to January 2017 in our hospital for treatment of 60 cases of neonatal necrotizing enterocolitis were as the research object, and to give a randomized, control group 30 cases, give simple phentolamine static drop treatment; Intervention group, 30 cases in the control group on the basis of small dose dopamine was given to two groups of children with fasting time, length of hospital stay, operation rate, efficacy and adverse reactions happen to comprehensive evaluation. Results The average fasting time and hospital length of the intervention group were significantly better than the control group (P< 0.05), which was statistically significant. Intervention group with operation rate and total effective rate were 3.3%, 93.3%, the control rate of surgery, treatment in children with total effective rate of 16.7%, 70.0% respectively, there are statistically significant difference (P< 0.05); There were only two cases of adverse reaction in the intervention group, 6.7%, and the difference of 23.3% in the control group was statistically significant (P< 0.05). Conclusion On the basis of phentolamine treatment of neonatal necrotizing enterocolitis with small dose of dopamine was given to shortening the time of fasting and hospitalization time, decrease the rate of transit operation, and less adverse reaction, curative effect is distinct, worthy of clinical popularization and application.

phenol tolaminesmall doses of dopamineneonatal necrotic enterocolitisadverse reactions

王枫

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陕西省神木县医院 儿科,陕西 神木 719300

酚妥拉明 小剂量多巴胺 新生儿坏死性小肠结肠炎 不良反应

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(9)
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