首页|雷珠单抗玻璃体注射联合玻璃体切除术对比单纯玻璃体切除术治疗增殖性糖尿病视网膜病变临床分析

雷珠单抗玻璃体注射联合玻璃体切除术对比单纯玻璃体切除术治疗增殖性糖尿病视网膜病变临床分析

扫码查看
目的 探讨增殖性糖尿病视网膜病变(PDR)单行玻璃体切除术与术前注射雷注单抗治疗后再行玻璃体切术术治疗的临床效果.方法 依据临床治疗方案不同随机将陕西省人民医院2016年2月~2017年2月收治的64例PDR患者均分成观察组与对照组,其中32眼(37眼)单行玻璃体切除术的患者纳入对照组,其余32例(41眼)术前自玻璃体腔内注射0.5 mg雷珠单抗药物治疗后再行玻璃体切除术的患者纳入观察组.记录2组手术时间、术前/术后最佳矫正视力并进行组间比较,统计医源性裂孔、电频使用频度、玻璃体积血、前房积血在2组发生的情况.结果 观察组手术时间为(96.47±12.67)min明显短于对照组(128.56±13.78)min(P<0.05).术前2组最佳矫正视力基本处于同一基线水平,术后30 d观察组最佳矫正视力明显提高且优于对照组(P<0.05).与对照组比较,观察组医源性裂孔、电凝使用频度、玻璃体积血、前房积血发生率明显要低(P<0.05).结论 经玻璃体腔注射雷珠单抗药物治疗后再行玻璃体切除术的联合方案在PDR治疗中应用安全有效,不仅有助于缩短手术时间,而且术后并发症发生率低,对患者术后视力恢复十分有益,值得临床广泛应用与推广.
Clinical analysis of vitreous resection combined with vitrectomy combined with vitrectomy for proliferative diabetic retinopathy
Objective To investigate the clinical effect of vitrectomy with single slice vitrectomy (PDR) and preoperative injection of monoclonal antibody (mAb) for treatment of proliferative diabetic retinopathy. Methods According to clinical treatment were randomly 64 cases of PDR patients in our hospital in February 2016-February 2017 were divided into observation group and control group, 32 cases (37 eyes) single vitreous body resection were included in the control group, the remaining 32 cases (41 eyes) from preoperative intravitreal injection 0.5mg Lei Zhu monoclonal antibody drug treatment after resection of vitreous body were included in the observation group. The operation time, the best corrected visual acuity before and after the operation were recorded and compared between the two groups. The incidence of iatrogenic hiatus, frequency use, vitreous volume and hyphema were recorded in the two groups. Results The operation time of the observation group was (96.47±12.67) min, which was significantly shorter than that of the control group (128.56±13.78) min (P<0.05). The best corrected visual acuity of the two groups was basically at the same baseline level, and the corrected visual acuity of the 30d observation group was obviously improved and better than that of the control group (P<0.05). Compared with the control group, the incidence of iatrogenic hiatus, electrocoagulation, vitreous volume and hyphema was lower in the observation group (P<0.05). Conclusion Intravitreal injection of ranibizumab therapy after resection of vitreous body regimen in the treatment of PDR is safe and effective, not only helps to shorten the operation time, and lower incidence of postoperative complications, postoperative recovery of visual acuity is good, it is worthy of clinical popularization and wide application of bed.

rabeprazolevitrectomyproliferative diabetic retinopathy

张坚、张健、张乐

展开 >

陕西省人民医院 眼科,陕西 西安 710068

韩城市人民医院 眼科,陕西 韩城 715400

雷珠单抗 玻璃体切除术 增殖性糖尿病视网膜病变

陕西省社发攻关基金

2014K11-01-01-23

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(9)
  • 6
  • 5