Effect of itraconazole capsules combined with clotrimazole vaginal tablets on patients with fungal vaginitis
Objective To investigate the effect of itraconazole capsules combined with clotrimazole on the quality of life and the incidence of adverse reactions in patients with fungal vaginitis. Methods From May 2014 to February 2016, 106 cases of fungal vaginitis patients were randomly divided into single drug group and combination drug group, 53 cases each group. The single drug group was treated with clotrimazole vaginal tablets, the combination drug group was treated with itraconazole capsules combined with clotrimazole vaginal tablets, both groups were treated for 15 d. Quality of life score(QOL-100) before and after treatment was compared, and the incidence of adverse reactions and clinical efficacy between the two groups were compared as well. Results The total effective rate was 96.23％ (51/53) in the combination drug group and 81.13％ (43/53) in the single drug group, the difference was statistically significant (P<0.05); The QOL-100 score of the combination group was higher than that of the single drug group, the difference was statistically significant (P<0.05); However, there was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Itraconazole capsules combined with clotrimazole vaginal tablets in the treatment of fungal vaginitis can effectively improve patients' quality of life, the effect is exact and no obvious adverse reactions was observed.
itraconazole capsulesclotrimazole vaginal tabletsfungal vaginitisquality of life
NETL
NSTL
万方数据
维普
