伊曲康唑胶囊联合克霉唑阴道片治疗霉菌性阴道炎患者观察疗效
Effect of itraconazole capsules combined with clotrimazole vaginal tablets on patients with fungal vaginitis
姚艳1
作者信息
- 1. 新疆伊犁州奎屯医院 妇产科,新疆 伊犁 833200
- 折叠
摘要
目的 探讨伊曲康唑胶囊联合克霉唑阴道片对霉菌性阴道炎患者生活质量及不良反应发生率的影响.方法 选取2014年5月～2016年2月106例霉菌性阴道炎患者作为研究对象,采用随机数字表法分为单一用药组和联合用药组,各53例.单一用药组采用克霉唑阴道片治疗,联合用药组予以伊曲康唑胶囊联合克霉唑阴道片治疗,均治疗15 d.统计对比2组治疗前后生活质量评分(QOL-100),不良反应发生率及临床疗效.结果 联合用药组治疗总有效率96.23％(51/53),高于单一用药组的81.13％(43/53),差异具有统计学意义(P<0.05);治疗后联合用药组QOL-100评分高于单一用药组,差异有统计学意义(P<0.05);2组不良反应发生率比较,差异无统计学意义.结论 伊曲康唑胶囊与克霉唑阴道片联合治疗霉菌性阴道炎,可有效提高患者生活质量,疗效确切且无明显不良反应.
Abstract
Objective To investigate the effect of itraconazole capsules combined with clotrimazole on the quality of life and the incidence of adverse reactions in patients with fungal vaginitis. Methods From May 2014 to February 2016, 106 cases of fungal vaginitis patients were randomly divided into single drug group and combination drug group, 53 cases each group. The single drug group was treated with clotrimazole vaginal tablets, the combination drug group was treated with itraconazole capsules combined with clotrimazole vaginal tablets, both groups were treated for 15 d. Quality of life score(QOL-100) before and after treatment was compared, and the incidence of adverse reactions and clinical efficacy between the two groups were compared as well. Results The total effective rate was 96.23％ (51/53) in the combination drug group and 81.13％ (43/53) in the single drug group, the difference was statistically significant (P<0.05); The QOL-100 score of the combination group was higher than that of the single drug group, the difference was statistically significant (P<0.05); However, there was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Itraconazole capsules combined with clotrimazole vaginal tablets in the treatment of fungal vaginitis can effectively improve patients' quality of life, the effect is exact and no obvious adverse reactions was observed.
关键词
伊曲康唑胶囊/克霉唑阴道片/霉菌性阴道炎/生活质量Key words
itraconazole capsules/clotrimazole vaginal tablets/fungal vaginitis/quality of life引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据