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米非司酮治疗早期异位妊娠的有效性及对患者生育力的影响

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目的 探讨米非司酮治疗早期异位妊娠的有效性及对患者生育力的影响.方法 选取2011年1月~2012年12月本院收治的早期异位妊娠患者90例,随机分为2组,对照组应用甲喋呤治疗,研究组联合应用米非司酮治疗,对比2组患者治疗有效性以及生育力.结果 治疗前2组患者的β-HCG(人绒毛膜促性腺激素)以及包块直径无明显区别,治疗后均得到一定改善,研究组显著优于对照组(P<0.05);2组患者生育力对比方面,随访2年后研究组患者宫内妊娠率显著高于对照组(P<0.05),异位妊娠以及继发性不孕率显著低于对照组(P<0.05);研究组患者的治疗有效率高于对照组同时不良反应发生率低于对照组(P<0.05).结论 早期异位妊娠患者应米非司酮治疗的效果理想,有利于保留患者生育力.
Effect of mifepristone on early ectopic pregnancy and its effect on fertility
Objective To investigate the efficacy of mifepristone in the treatment of early ectopic pregnancy and its effect on the fertility of patients. Methods 90 patients with early ectopic pregnancy admitted in our hospital from January 2011 to December 2012 were randomly divided into two groups. The control group was treated with methotrexate. The combination group was treated with mifepristone. Patient treatment effectiveness and fertility. Results There were no significant differences in β-HCG (human chorionic gonadotropin) and mass in the two groups before treatment. After treatment, the patients were significantly improved, the study group was significantly better than the control group (P<0.05). The rate of intrauterine pregnancy was significantly higher in the study group than that in the control group (P<0.05). The rate of ectopic pregnancy and secondary infertility were significantly lower than those of the control group (P<0.05 ). The incidence of adverse reactions in the study group was lower than that in the control group (P<0.05). Conclusion The efficacy of mifepristone in the treatment of early ectopic pregnancy is ideal for the retention of patient fertility and should be promoted.

mifepristonemethotrexateearly ectopic pregnancyeffectivenessfertility

张丽莉、赖海清

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福建省厦门市妇幼保健院 妇科,福建 厦门 361000

米非司酮 甲喋呤(甲氨蝶呤) 早期异位妊娠 有效性 生育力

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(9)
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