首页|放射治疗与89Sr核素治疗对椎骨转移癌性疼痛的临床疗效比较分析

放射治疗与89Sr核素治疗对椎骨转移癌性疼痛的临床疗效比较分析

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目的 探讨椎骨转移癌性疼痛采用89Sr核素治疗与放射治疗效果对比情况.方法 选择椎骨转移癌性疼痛患者80例,均为宜宾市第二人民医院2015年4月~2017年4月收治,随机分组,就采用放射方案治疗(对照组,n=40)与采用89Sr核素治疗(观察组,n=40)效果展开对比.结果 观察组选取的椎骨转移癌性疼痛患者疼痛反应改善总有效率经统计为85.0%,对照组为82.5%,对比差异无统计学意义.观察组治疗方案起效时间经观察为(6.5±1.7)d,明显短于对照组(12.9±2.6)d,差异具统计学意义(P<0.05).结论 椎骨转移性疼痛采用89Sr核素治疗,在改善疼痛反应方面作用同放射治疗相当,但药效在短时间内即可发挥,故更值得在临床广泛推广应用.
Comparative analysis of radiotherapy and 89Sr radionuclide therapy in the treatment of cervical metastatic cancer pain
Objective To compare the effect of 89Sr radionuclide therapy and radiotherapy in the treatment of metastatic cancer pain of vertebral column. Methods 80 patients with cancer pain of vertebral metastasis in the second People's hospital of Yibin from April 2015 to April 2017, were randomly divided into the control group treated by radiotherapy treatment (n=40) and the the observation group treated by 89Sr radionuclide therapy(n=40), and the effect of treatment were compared between two groups. Results In the observation group, the total effective rate of pain response in patients with metastatic cancer pain of vertebral column was 85.0%, and the control group was 82.5%. There was no significant difference between two groups. The onset time of treatment in the observation group was (6.5±1.7)d, significantly shorter than that of the control group (12.9±2.6)d, and the difference was statistically significance (P<0.05). Conclusion The application of 89Sr radionuclide therapy in the treatment of vertebral metastatic pain is equivalent to the radiotherapy in improving the pain response, but the efficacy could be achieved in a short period of time, so it is worth popularizing widely in clinical practice.

radiotherapy89Sr nuclidevertebral metastasiscancerous paincomparison of effect

杨琦、汪建强、周凡、樊雪缘、钟俐强、贾钰铭

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宜宾市第二人民医院 核医学科,四川 宜宾 644000

宜宾市第二人民医院 肿瘤科,四川 宜宾 644000

放射治疗 89Sr核素 椎骨转移癌性疼痛 效果对比

四川省医学科研青年创新课题计划

Q15085

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(9)
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