羟基酪醇的生物活性研究进展
Research Progress on Bioactivity of Hydroxytyrosol
吴季栩 1郭新艳 2孟祥璟 2刘飞 1凌沛学1
作者信息
- 1. 山东大学 药学院,山东 济南 250101;山东省药学科学院 生物药物重点实验室 多糖药物工程实验室 多糖药物发酵与精制国家地方联合工程实验室,山东 济南 250101
- 2. 山东省药学科学院 生物药物重点实验室 多糖药物工程实验室 多糖药物发酵与精制国家地方联合工程实验室,山东 济南 250101
- 折叠
摘要
橄榄油是农产品中重要副产品之一,富含橄榄苦蛋白,可以水解成几种生物活性酚类化合物,包括羟基酪醇(hydroxytyrosol,HT).文献报道HT在抗炎、抗HIV、调控代谢紊乱和治疗退行性疾病等方面具有生物活性.但是,HT在体内外有明显的不稳定性,如何对其进行结构改造或利用制剂手段对其进行"加工包装"以提高稳定性是目前HT研究的一大难点.为此,本文将针对HT的生物活性和提高其稳定性的方法 两个方面进行综述,为拓展HT在医药领域的应用提供思路.
Abstract
Olive oil is one of the important byproducts in agriculture. It is rich in oleuropein, which can be hydrolyzed into several bioactive phenolic compounds, including hydroxytyrosol (HT).There are many literatures have been confirmed that HT has significant pharmacological effects in the anti-inflammatory, anti-virus, regulation of metabolic disorders and treatment of degenerative diseases. However, HT has severe instability in vivo and in vitro. It is a challenge how to improve its stability through structural transformation or utilization of pharmaceutical means to processing. This paper will focus on biological activity of HT and its stability improvement, and provid some new ideas for expanding the research and promoting the development of HT in the field of Medicine.
关键词
羟基酪醇/生物活性/不稳定性/进展Key words
hydroxytyrosol/bioactivity/instability/progress引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据