首页|中药人参养荣汤联合肠内营养对中晚期结肠癌患者化疗期间营养状况的观察

中药人参养荣汤联合肠内营养对中晚期结肠癌患者化疗期间营养状况的观察

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目的 观察中晚期结肠癌患者化疗期间应用中药人参养荣汤联合肠内营养对其营养状况的影响.方法 采取前瞻性研究方法对中国人民解放军总医院中医科2014年1月~2017年1月入选的160例中晚期结肠癌行化疗患者的临床资料进行分析.采用随机数表将80例患者分为治疗组和对照组,每组各40例,治疗组患者化疗期间给予中药人参养荣汤及肠内营养支持治疗,对照组患者化疗期间单纯给予肠内营养支持治疗.比较2组患者的各项营养指标、临床疗效、不良反应和免疫指标.结果 治疗组RR67.50%高于对照组35.00%,DCR57.50%高于对照组52.50%,但组间差异无统计学意义;2组患者行1疗程化疗后相关营养指标的比较提示:治疗组患者的体质量指数、肱三头肌皮褶厚度、上臂肌围、总蛋白、白蛋白、前白蛋白水平均优于对照组,差异有统计学意义(P<0.05);2组主要不良反应为白细胞减少、血小板减少、血红蛋白减少、恶心呕吐、心律失常、纳差、脱发、发热等,2组不良反应发生率,差异有统计学意义(P<0.05);治疗组TLC、IgG、IgM均明显高于对照组,差异有统计学意义(P<0.01).结论 人参养荣汤对中晚期结肠癌化疗患者的营养状况能够起到一定的改善作用,降低患者不良反应,有效提高患者的免疫功能.
Observation nutritional status of advanced colon cancer patients undergoing chemotherapy with Ginseng nutrient nourishing decoction assisted with enteral nutrition
Objective To observe the effect of Chinese herbal medicine Ginseng nutrient-nourishing decoction combined with enteral nutrition on its nutritional status during chemotherapy in patients with advanced colon cancer. Methods A prospective study was conducted to analyze the clinical data of 160 patients with advanced colorectal cancer who were enrolled in the Chinese Medicine Section of the PLA General Hospital from January 2014 to January 2017. 160 patients were divided into treatment group and control group, 80 patients in each group. The patients in the treatment group were given traditional Chinese medicine Ginsengnutyient-nourishing decoction and enteral nutrition support treatment. The control group was given enteral nutrition Support treatment. The nutritional indicators, clinical efficacy, adverse reactions and immune indicators were compared between the two groups. Results The RR67.50% of the treatment group was higher than the control group (35.00%), and the DCR57.50% was higher than that of the control group (52.50%), but there was no significant difference between the two groups. Compared with the control group, the body mass index of the treatment group, the thickness of the triceps skin fold, the upper arm muscle, the total protein, the albumin and the prealbumin were better than the control group, the diffiences was statistically significant (P<0.05). The incidence of thrombocytopenia, thrombocytopenia, hemoglobin reduction, nausea and vomiting, arrhythmia, anorexia, alopecia and fever were significantly different between the two groups (P<0.05) , IgM (all significantly higher than the control group, the difference between the two groups was statistically significant (P<0.05). Conclusion Ginseng nutrient-nourishing decoction can improve the nutritional status of patients with advanced colon cancer chemotherapy, can play a role in reducing the adverse reactions of patients, effectively improve the immune function of patients, it is worth promoting.

chemotherapyadvanced colon cancerenteral nutritionGinseng nutrient-nourishing decoctionnutritional status

廖芸、徐玉芬

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丽水市中医院 消化内科,浙江 丽水 323000

嘉兴市第一医院 肿瘤科,浙江 嘉兴 314000

化疗 中晚期结肠癌 肠内营养 人参养荣汤 营养状况

浙江省中医药科技计划项目浙江省医药卫生科技计划项目嘉兴市重点学科(肿瘤)项目

2015ZQ0342016KYB29004-F-14

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(10)
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