首页|恩替卡韦联合扶正化瘀胶囊对代偿期慢性乙型肝炎肝硬化患者炎性因子及纤维化指标的影响

恩替卡韦联合扶正化瘀胶囊对代偿期慢性乙型肝炎肝硬化患者炎性因子及纤维化指标的影响

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目的 探究为代偿期慢性乙型肝炎肝硬化患者行恩替卡韦联合扶正化瘀胶囊治疗的临床疗效.方法 择取2015年5月~2017年5月期间收治的102例代偿期慢性乙型肝炎肝硬化患者,通过随机数字法平均分为研究组与对照组,2组患者均行常规对症与保肝治疗,对照组基于此行恩替卡韦治疗,研究组则在常规疗法基础上行恩替卡韦联合扶正化瘀胶囊治疗,比较2组患者的HBV DNA转阴率、炎性因子变化、纤维化指标以及肝功能指标.结果 2组患者临床观察指标均有改善,且转阴率差异无统计学意义;但是研究组患者的炎性因子、纤维化指标以及肝功能指标改善相比对照组更为显著,数据差异存在统计学意义(P<0.05).结论 为代偿期慢性乙型肝炎肝硬化患者行恩替卡韦联合扶正化瘀胶囊治疗的临床疗效确切,值得在临床中推广和应用.
Effect of entecavir combined with fuzheng huayu capsule on inflammatory factors and fibrosis index in patients with chronic hepatitis b cirrhosis
Objective To explore the clinical efficacy of entecavir combined with Fuzheng Huayu capsule in patients with chronic hepatitis B cirrhosis. Methods A total of 102 decompensated patients with chronic hepatitis B cirrhosis were enrolled in our hospital from May 2015 to May 2017. The patients were divided into study group and control group by random number method. The patients were treated with routine symptom and liver Treatment group, based on this line of entecavir treatment, the study group in the conventional therapy based on entecavir combined with Fuzheng Huayu capsule treatment, compared the two groups of patients with HBV DNA negative rate, inflammatory factors, fibrosis indicators and liver function indicators. Results However, the improvement of inflammatory factors, fibrosis indexes and liver function indexes in the study group was more significant than that in the control group, and the difference was significant, but there was no significant difference between the two groups There was statistical significance (P<0.05). Conclusion The efficacy of entecavir combined with Fuzheng Huayu capsule in patients with chronic hepatitis B liver cirrhosis is accurate and worthy of clinical application in clinical practice.

entecavirfuzheng huayu capsulechronic hepatitis bdecompensationcirrhosisinflammatory factorfibrosis index

杨妍、锁忠岐

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宁夏回族自治区人民医院 感染科,宁夏 750021

宁夏同心县预旺镇卫生院,宁夏 751305

恩替卡韦 扶正化瘀胶囊 慢性乙型肝炎 代偿期 肝硬化 炎性因子 纤维化指标

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(10)
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