首页|补肾活血通络方加减辨治原发性膝骨性关节炎急性发作的临床研究

补肾活血通络方加减辨治原发性膝骨性关节炎急性发作的临床研究

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目的 探讨补肾活血通络方加减治疗原发性膝骨性关节炎急性发作临床效果,以期丰富治疗方法,提高疗效.方法 将94例原发性膝骨性关节炎急性发作随机分成2组,对照组47例,予常规西药治疗,观察组47例,加用补肾活血通络方,观察治疗后安全性指标、血清学指标和相关评分改善情况.结果 2组治疗后在疼痛、僵硬、日常生活能力、压痛、肿胀、关节活动度上均显著低于治疗前,治疗前后比较差异具有统计学意义(P<0.05),治疗后观察组在以上六个指标上显著优于对照组(P<0.05).2组治疗后在MMP-3、CRP、IL-1、TNF-α显著低于治疗前,治疗前后比较差异具有统计学意义(P<0.05),治疗后观察组以上指标显著优于对照组(P<0.05).结论 补肾活血通络方能改善原发性膝骨性关节炎急性发作临床症状,降低炎症反应,且安全性高.
Clinical study on treatment of primary attack of knee osteoarthritis with bushen Huoxuetongluo decoction
Objective To investigate the clinical effect of Bushen Huoxue Tongluo Recipe in the treatment of acute attack of primary knee osteoarthritis, so as to enrich the treatment method and improve the curative effect. Methods 94 cases of primary knee osteoarthritis acute attack were randomly divided into 2 groups, 47 cases in the control group were treated with conventional western medicine treatment, the observation group of 47 cases, treated with Bushen Huoxue Tongluo Decoction, were observed after treatment in the improvement of the safety index, serum indexes and related score. Results The two groups at the end of the pain, stiffness, ADL, tenderness, swelling, joint activities are significantly lower than before treatment, after treatment were significantly different (P<0.05) at the end of treatment, the observation group in the above six indicators were significantly better than the control group (P<0.05); group MMP-3, two at the end of treatment CRP, IL-1, TNF- were significantly lower than before treatment, after treatment were significantly different (P<0.05) at the end of treatment observation group above index was significantly better than the control group (P<0.05). Conclusion: Bushen Huoxue Tongluo Decoction can improve the primary acute exacerbation of knee osteoarthritis clinical symptoms, reduce inflammation, and high safety.

Bushen Huoxue Tongluo recipeprimary osteoarthritis of the kneeacute attackcurative effect

陈剑强、张小芳

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浙江省荣军医院,浙江 嘉兴 314001

补肾活血通络方 原发性膝骨性关节炎 急性发作 疗效

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(10)
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