阿替普酶早期静脉溶栓对急性期脑梗塞的疗效分析
Effect of early intravenous thrombolysis with an alteplase on the patients with acute cerebral infarction
雷青梅 1梁鹏飞1
作者信息
- 1. 山西省平遥县人民医院 神经内科,山西 晋中 031100
- 折叠
摘要
目的 探讨应用阿替普酶(rt-PA)静脉溶栓对急性脑梗塞(ACI)治疗的临床效果.方法 选择山西省平遥县人民医院40例急性脑梗塞患者,治疗时间窗未发病时间小于3 h,将其分为rt-PA组与对照组,每组20例;rt-PA组在给予常规脑梗塞药物治疗的基础上,给予rt-PA静脉溶栓治疗,对照组给予奥扎格雷钠进行治疗.采用美国国立卫生研究院卒中量表(NIHSS)及Barthel指数(BI)进行疗效及安全性评价.结果 2组患者治疗后NIHSS评分较治疗前明显改善,rt-PA组改善效果显著优于对照组(P<0.05);治疗21天时,rt-PA组显效率为80.00%,BI≥95分的比率为40.00%,对照组显效率为25%,BI≥95分的比率为20.00%,rt-PA组显著高于对照组(P<0.01);2组病死率、继发性脑出血及血管再闭塞发生率在2组之间差异无统计学意义.结论 在ACI发病3 h内给予患者rt-PA静脉溶栓治疗较奥扎格雷钠更安全、更有效.
Abstract
Objective To investigate the clinical effect of of rt-Pa Early Thrombolytic Therapy on the Patients with Acute Cerebral Infarction (ACI). Methods 40 patients with acute cerebral infarction were randomly divided into rt-PA group and control group, 20 cases in each group. The treatment time window was less than 3 hours. On the basis of the routine medication of cerebral infarction, rt-PA group was given rt-PA intravenous thrombolytic therapy, the control group was treated with sodium ozagrel. The National Institutes of Health Stroke Scale (NIHSS) and Barthel index (BI) were used to evaluate the efficacy and safety. Results The NIHSS scores of two groups after treatment were significantly improved compared with before treatment, rt-PA group improved significantly better than the control group (P<0.05); At 21 days of treatment, the excellence rate of rt-PA group was 80% and the ratio of BI≥95 was 40.00%, the excellence rate of control group was 25.0% and the ratio of BI≥95 was 20.00%, the rt-PA group was significantly higher than the control Group (P<0.01); there was no significant difference between the two groups in the mortality rate, the incidence of secondary cerebral hemorrhage and vascular restenosis in the two groups. Conclusion Within 3 hours of onset of ACI, compared with the sodium ozagrel therapy, the rt-PA intravenous thrombolytic therapy is more safe and effective in the treatment of ACI patients, and it is worthy to be widely used in clinical treatment.
关键词
阿替普酶/急性脑梗塞/奥扎格雷钠/静脉溶栓Key words
rt-PA/acute Cerebral Infarction/sodium ozagrel/thrombolytic therapy引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据