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长期服用抗精神病药对心电图QTc(QT间期)影响的临床观察

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目的 探索长期服用抗精神病药对心电图QTc的临床影响.方法 选取2016年5月22日~2017年5月22日期间收治100例精神分裂症患者为实验对象,且均实施抗精神病药治疗,其中26例患者选用氟哌啶醇治疗,34例患者选用氯丙嗪治疗,19例患者选用舒必利治疗,21例患者选用奋乃静,随后分析不同药物治疗后的心电图改变、治疗前后QT/QTc间期>400 ms发生率.结果 氟哌啶醇治疗后QT为(376.36±12.18)ms,QTc为(414.96±14.56)ms;奋乃静治疗后QT为(378.15±15.43)ms,QTc为(407.36±12.75)ms;舒必利治疗后QT为(382.15±13.85)ms,QTc为(401.86±15.86)ms;氯丙嗪治疗后QT为(382.12±13.24)ms,QTc为(396.35±12.05)ms.氟哌啶醇治疗后QT/QTc间期>400 ms发生率高于治疗前,差异具有统计学意义(P<0.05),氯丙嗪、舒必利、奋乃静经治疗后和治疗前的QT/QTc间期>400 ms发生率比较,差异无统计学意义.结论 不同抗精神病药可对心电图QTc造成不同影响,奋乃静、舒必利、氯丙嗪、氟哌啶醇均可降低心电图的电压.
Clinical observation of long - term effect of antipsychotics on electrocardiogram QTc
Objective To explore the clinical effect of long-term use of antipsychotic drugs on electrocardiogram QTc. Methods A total of 100 patients with schizophrenia were enrolled from May 22, 2016 to May 22, 2017, and antipsychotics were treated. Of the 26 patients, haloperidol was treated with haloperidol and 34 patients were treated with chlorine Propoxazine treatment, 19 patients were treated with sulpiride, 21 patients were treated with perphenazine, followed by analysis of different drugs after treatment of ECG changes, before and after treatment QT / QTc interval>400 ms incidence. Results QT was (376.36 ± 12.18) ms and QTc was (414.96 ± 14.56) ms after haloperidol treatment, and the QT was (378.15 ± 15.43) ms and the QTc was (407.36 ± 12.75) ms after perphenazine treatment; After treatment, QT was (382.15 ± 13.85) ms and QTc was (401.86 ± 15.86) ms. QT was (382.12 ± 13.24) ms and QTc was (396.35 ± 12.05) ms after chlorpromazine treatment. (P <0.05). The QT / QTc interval was more than 400 hours after treatment (P <0.05). The incidence of QT / QTc interval> 400ms after haloperidol treatment was higher than that before treatment (P <0.05), chlorpromazine, sulpiride, There was no difference in the rate . Conclusion Long-term use of antipsychotic drugs can affect the ECG QTc.

antipsychoticselectrocardiogramQTc

余琳琳、舒孝萧

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宁波大学医学院附属鄞州医院 心电图,浙江 宁波 315100

抗精神病药 心电图 QT间期

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(10)
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