甲基强的松龙与丙种球蛋白联合治疗急性脊髓炎的对比观察
Comparative observation of Methylprednisolone and gamma globulin in the treatment of acute myelitis
李娟 1周军 2展淑琴3
作者信息
- 1. 西安交通大学第二附属医院 神经内科,陕西 西安 710004;商洛市中心医院 神经内科,陕西 商洛 726000
- 2. 商洛市中心医院 神经内科,陕西 商洛 726000
- 3. 西安交通大学第二附属医院 神经内科,陕西 西安 710004
- 折叠
摘要
目的 分析甲基强的松龙与丙种球蛋白联合治疗急性脊髓炎的疗效.方法 选取西安交通大学第二附属医院收治的100例急性脊髓炎患者为研究对象,对照组进行地塞米松进行治疗,实验组进行丙种球蛋白联合甲基强的松龙治疗.比较分析实验组与对照组临床疗效、不良反应及相关临床指标.结果 经实验组治疗有效率为92.0%,对照组治疗有效率为82.0%,差异具有统计学差异(P<0.05).2组患者均未出现明显不良反应,发生率分别为8.0%与10.0%,差异无统计学意义.对照组肌力改善2级时间为(18.90±5.23)d,显著长于实验组(10.87±4.30)d,实验组住院时间、感觉恢复时间及排尿功能恢复等指标均优于对照组,差异具有统计学意义(P<0.05).结论 甲基强的松龙与丙种球蛋白联合治疗急性脊髓炎临床效果理想,能够显著改善患者肌力,安全性较高.
Abstract
Objective To study and analyze the efficacy of Methylprednisolone and gamma globulin in the treatment of acute myelitis. Methods 100 cases of acute myelitis in the second affiliated hospital of Xi'an Jiaotong University were selected as the research objects, and the control group was treated with Dexamethasone. The experimental group was treated with Methylprednisolone combined with gamma globulin. The clinical efficacy, adverse reactions and related clinical indicators of the experimental group and the control group were compared and analyzed. Results The effective rate of the experimental group (92.0 %) was significantly better than (82.0 %) of the control group with statistical difference (P<0.05). There were no obvious adverse reactions in the two groups, the incidence rate was 8.0% and 10.0 % respectively, and there was no significant difference. Time of muscle strength improved two level in the control group (18.90±5.23) d was significantly longer than that (10.87±4.30) d of the experimental group, the experimental group hospitalization time, sensory recovery time and recovery of urinary function and other indicators are better than the control group, with statistical difference (P<0.05). Conclusion Methylprednisolone combined with gamma globulin in the treatment of acute myelitis has ideal efficacy, could significantly improve the patient's muscle strength with high safety.
关键词
甲基强的松龙/急性脊髓炎/丙种球蛋白/临床疗效Key words
Methylprednisolone/acute myelitis/gamma globulin/clinical efficacy引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据