右美托咪定复合瑞芬太尼对ICU术后机械通气患者的镇静效果分析
Analysis of sedative effect of dexmedetomidine combined with remifentanil in patients with mechanical ventilation after ICU surgery
王平 1金伟盛 1王才木 1荀凯2
作者信息
- 1. 宁海县第一医院 ICU,浙江 宁波 315600
- 2. 宁波市第二医院 急诊科, 浙江 宁波 315010
- 折叠
摘要
目的 探讨右美托咪定复合瑞芬太尼对ICU术后行机械通气患者的镇痛效果.方法 将收治的120例ICU术后行机械通气患者按照随机数字表法分为对照组(丙泊酚复合瑞芬太尼)与观察组(右美托咪定复合瑞芬太尼),每组60例.记录并比较2组镇静时间、停药后苏醒时间、镇痛效果及不良反应等.结果 观察组患者焦虑自评量表(SAS)评分、重症监护室疼痛观察工具法(CPOT)评分分别为(3.98±0.52)分、(2.23±1.04)分,明显低于对照组(4.36±0.96)分、(3.46±2.23)分,2组比较差异具有统计学意义(P<0.05);观察组镇静时间、停药后苏醒时间分别为(691.28±236.58)min、(1.22±0.05)min明显短于对照组(2642.33±341.58)min、(3.56±0.74)min,2组比较差异具有统计学意义(P<0.05).观察组不良反应发生率3.33%(2/60),明显低于对照组13.33%(8/60),2组比较差异具有统计学意义(χ2=3.92,P=0.04).结论 ICU术后行机械通气患者应用右美托咪定复合瑞芬太尼具有较好的镇痛效果,且有利于患者苏醒,不良反应少.
Abstract
Objective investigate the analgesic effect of dexmedetomidine combined with remifentanil in patients with mechanical ventilation after ICU surgery. Methods 120 patients with ICU underwent mechanical ventilation were divided into control group (propofol combined remifentanil) and observation group (dexmedetomidine remifentanil) according to the random number table method, 60 cases each group. Record the two groups of total sedation time, withdrawal time after the withdrawal, analgesic effect, adverse reactions. Results The scores of SAS score and CPOT were (3.98±0.52) and (2.23±1.04), respectively, which were significantly lower than those in the control group (4.36±0.96) and (3.46±2.23), respectively (P<0.05). (691.28±236.58) min and (1.22±0.05) min were significantly shorter than those in the control group (2642.33±341.58) min, (3.56±0.74) min, P<0.05, respectively. The adverse reaction rate was 3.33% (2/60) in the observation group, which was significantly lower than that in the control group (13.33%, 8/60),( χ2=3.92, P=0.04). Conclusion ICU postoperative mechanical ventilation patients with dexmedetomidine combined with remifentanil has a good analgesic effect, and is conducive to the patient wake up, less adverse reactions, with a certain safety.
关键词
ICU/术后/机械通气/右美托咪定/瑞芬太尼Key words
ICU/postoperative/mechanical ventilation/dexmedetomidine/remifentanil引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据