首页|甲钴胺治疗糖尿病周围神经病变的疗效及对患者血浆同型半胱氨酸水平的影响

甲钴胺治疗糖尿病周围神经病变的疗效及对患者血浆同型半胱氨酸水平的影响

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目的 分析甲钴胺治疗糖尿病周围神经病变的疗效及与患者血浆同型半胱氨酸水平的相关性.方法 选择2013年1月~2016年8月接受治疗的糖尿病周围神经病变患者100例,按照入院ID号随机分为对照组与观察组,每组50例.同时搜集50名健康者为正常对照组.对照组与观察组患者均给予西医常规治疗,观察组同时给予甲钴胺治疗.比较3组实验者血浆同型半胱氨酸水平,并通过临床和电生理方法评估神经病变的改善程度.结果 观察组与对照组患者治疗前血浆同型半胱氨酸水平明显高于正常对照组.观察组经甲钴胺治疗后患者血浆同型半胱氨酸水平明显优于对照组,差异具有统计学意义(P<0.05).观察组患者神经病变症状和神经传导速度也较对照组有明显改善,差异具有统计学意义(P<0.05).结论 血浆同型半胱氨酸水平与糖尿病周围神经病变有着强相关性,而采用甲钴胺治疗糖尿病周围神经病变能够降低患者同型半胱氨酸水平,从而有效治疗糖尿病周围神经病变.
Effect of mecobalamin on diabetic peripheral neuropathy and its effect on plasma homocysteine
Objective To study the correlation analysis of mecobalamin in treatment of diabetic peripheral neuropathy and its plasma homocysteine level. Methods 100 patients were selected from January 2013 to August 2016 treatment of diabetic peripheral neuropathy, according to admission ID, were randomly divided into control group and observation group, each group of 50 people. At the same time, 50 healthy persons were collected as normal control group and two groups were given routine treatment of Western medicine. The observation group was given mecobalamin. The plasma levels of plasma homocysteine were detected in the three groups, and the improvement degree of neuropathy was assessed by clinical and electrophysiological methods. Results The observation group and the control group of patients before treatment, plasma homocysteine levels were significantly higher than normal control group; the observation group with Mecobalamin after treatment of plasma homocysteine level in patients were significantly better than the control group (P<0.05); through clinical and electrophysiological evaluation method of observation group of patients in the neuropathic symptoms and nerve conduction velocity is the control group improved significantly (P<0.05). Conclusion The levels of plasma homocysteine and diabetic peripheral neuropathy have a strong correlation, and the use of mecobalamin in treating diabetic peripheral neuropathy can decrease homocysteine levels in patients with, and is effective for the treatment of diabetic peripheral neuropathy, and can be widely applied in clinical treatment.

mecobalamindiabetic peripheral neuropathyplasma homocysteine

张艳丽、胡丽格、冯建军、黄丽梅、宋晓辉、魏亚兰、李素洁、孟哲、李伟

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邢台医学高等专科学校第一附属医院 普内科,河北 邢台 054000

临城县人民医院 药剂科,河北 邢台054300

甲钴胺 糖尿病周围神经病变 同型半胱氨酸

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(10)
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