急性冠脉综合征患者血清糖化血红蛋白和N末端脑钠肽原的临床检测价值
Clinical value of serum glycosylated hemoglobin and N-terminal brain natriuretic peptide in patients with acute coronary syndromes
章武战 1周亮良 1刘生华 1章国东1
作者信息
- 1. 金华文荣医院 检验科,浙江 金华 321017
- 折叠
摘要
目的 探讨检测急性冠脉综合征患者血清糖化血红蛋白(HbA1c)和N末端脑钠肽原(NT-proBNP)的意义.方法 选取金华文荣医院2015年6月~2016年12月期间120例急性冠脉综合征患者进行研究,其中伴糖尿病者68例(甲组)、不伴糖尿病者52例(乙组);另选取于医院进行健康体检的正常健康者80例为对照组.检测各组血清糖化血红蛋白(HbA1c)和N末端脑钠肽原(NT-proBNP)水平,并加以比较.结果 甲组患者血清HbA1c水平为(9.52±1.57)%,明显高于乙组(5.92±0.36)%和对照组(5.82±0.41)%,t=(16.19,20.29),P=(0.00,0.00);乙组与对照组比较,t=1.43,P=0.15.甲组血清NT-proBNP水平为(442.78±79.14)μg/mL,明显高于乙组(221.45±33.89)μg/mL、对照组(87.14±14.82)μg/mL,t=(18.87,39.41),P=(0.00,0.00);乙组明显高于对照组,t=31.19,P=0.00.急性冠脉综合征患者心功能与患者血清HbA1c、NT-proBNP呈正相关性(r=0.624、0.582).结论 急性冠脉综合征患者血清HbA1c、NT-proBNP呈升高趋势,尤其是NT-proBNP水平,临床通过检测急性冠脉综合征患者HbA1c、NT-proBNP水平可有助于评价其心功能.
Abstract
Objective To investigate the significance of serum HbA1c and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute coronary syndromes. Methods 120 patients with acute coronary syndromes were enrolled in Jinhua Wenrong hospital from June 2015 to December 2016. Among them, 68 patients with diabetes mellitus (group A) and 52 patients without diabetes (group B) were selected. 80 healthy cases in this hospital were selected as the control group. (HbA1c) and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured and compared. Results The level of serum HbA1c in group A was (9.52±1.57)%, which was significantly higher than that in group B (5.92±0.36)%, control group (5.82±0.41)%, t=(16.19, 20.29), P=(0.00, 0.00); And group B compared with the control group, t=1.43, P=0.15. The level of NT-proBNP in group A was (442.78±79.14) μg/mL, which was significantly higher than that in group B (221.45±33.89) μg/mL, control group (87.14±14.82) μg/mL, t=(18.87, 39.41), P= (0.00, 0.00); and group B was significantly higher than those in the control group, t=31.19, P=0.00. Cardiac function in patients with acute coronary syndromes was positively correlated with serum HbA1c and NT-proBNP (r=0.624, 0.582). Conclusion The levels of HbA1c and NT-proBNP in patients with acute coronary syndromes were significantly higher than those in patients with acute coronary syndromes. The levels of HbA1c and NT-proBNP in patients with acute coronary syndromes were helpful to evaluate their cardiac function.
关键词
糖化血红蛋白/冠心病/急性冠脉综合征/N末端脑钠肽原/心功能Key words
glycosylated hemoglobin/coronary heart disease/acute coronary syndrome/N-terminal brain natriuretic/cardiac function引用本文复制引用
基金项目
2015年度金华市科学技术研究计划(2015-3-076)
出版年
2017
NETL
NSTL
维普
万方数据