首页|血降钙素原和C反应蛋白对肝硬化腹水自发性腹膜炎的诊断意义

血降钙素原和C反应蛋白对肝硬化腹水自发性腹膜炎的诊断意义

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目的 评估血清血指标降钙素原(PCT)与C反应蛋白(CRP)在肝硬化自发性细菌性腹膜炎(SBP)诊断中的意义.方法 选取2010年1月~2015年1月安吉县人民医院消化科住院的已确诊肝硬化腹水合并自发性腹膜炎患者45例(肝硬化自发性腹膜炎组),未合并自发性腹膜炎患者52例(肝硬化非腹膜炎组),采用免疫发光法检测2组血清PCT水平,采用胶乳增强免疫比浊法检测2组血清CRP水平,并比较2组指标的差异性.结果 与无SBP组相比,SBP组患者PCT、CRP值均显著升高.与单独检测相比,二者联合检测对SBP诊断的敏感性、特异性更高.结论 PCT和CRP联合检测对于SBP诊断具有较好的特异性、敏感性,可以作为肝硬化合并SBP患者的早期诊断指标.
Diagnostic value of serum procalcitonin and C-Reactive protein in cirrhosis ascites patients with spontaneous peritonitis
Objective To evaluate the diagnostic value of serum procalcitonin (PCT) and C-Reactive protein(CRP) in cirrhosis patients with spontaneous peritonitis(SBP). Methods 45 cirrhosis patients with SBP(cirrhosis, spontaneous peritonitis group) and 52 cirrhosis patients without SBP(cirrhosis, non peritonitis group) in the department of Gastroenterology, Anji people's Hospital from January 2010 to January 2015 were enrolled, the serum PCT levels of 2 groups were detected by immune luminescence, and the serum CRP levels of 2 groups were detected by latex enhanced turbidimetric immunoassay, then the differences between the two groups were compared. Results Compared with cirrhosis patients without SBP, the PCT and CRP level have significantly increased in cirrhosis patients with SBP, and the sensitivity and specificity of PCT were higher than CRP, also, PCT combined with CRP test was more sensitive and specific than tested alone. Conclusion PCT combined with CRP test have great sensitivity and specificity in the diagnosis of cirrhosis ascites patients with SBP, and can be considered as the early diagnostic indictors of SBP.

cirrhosis ascitesspontaneous peritonitisserum procalcitoninC-Reactive protein

石晓红、江文华

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安吉县人民医院 消化科,浙江 湖州 313300

肝硬化腹水 自发性腹膜炎 降钙素原 C反应蛋白

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(10)
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