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药物难治性癫痫MRI表现与脑电图及病理对照研究

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目的 探讨药物难治性癫痫MRI与脑电图检查结果、病理检查结果的对照情况.方法 选择经系统抗癫痫药物治疗后仍无法控制其病情的70例药物难治性癫痫患者,对其分别给予MRI、EEG、病理检查.记录70例患者MRI、EEG及病理检查结果,经统计分析后得出结论.结果 与病理检查相比,MRI检查对致痫灶及相关病变的定位准确率为88.57%,EEG检查对致痫灶及相关病变的定位准确率为51.43%,差异有统计学意义(P<0.05);MRI检查对致痫灶及相关病变定性准确率为75.71%.结论 对于药物难治性癫痫患者,MRI检查与病理检查符合率较高,相较于EEG可为临床医生提供更为可靠的药物难治性癫痫诊治依据,有利于患者的疗效.
Comparative study of MRI manifestations and EEG and pathology of drug refractory epilepsy
Objective To investigate the results of MRI and electroencephalogram examination and pathological examination of drug refractory epilepsy. Methods 70 cases with drug refractory epilepsy were treated with systemic antiepileptic drugs, but they still could not control their condition, and they were given MRI, EEG and pathological examination respectively. MRI, EEG and pathological findings of 70 cases were recorded, and the conclusion was drawn after statistical analysis. Results Compared with pathological examination, the localization accuracy of MRI for epileptogenic foci and related lesions was 88.57%, the accuracy of localization of EEG for epileptogenic foci and related disease was 51.43%, the difference was statistically significant (P<0.05); MRI examination of the epileptogenic lesions and qualitative accuracy the rate of up to 75.71%. Conclusion According to the patients with drug intractable epilepsy, the coincidence rate of MRI examination and pathological examination is higher. Compared with EEG, it can provide clinicians with more reliable basis for the diagnosis and treatment of drug refractory epilepsy. It is helpful to protect the curative effect of these patients.

drug intractable epilepsyMRIEEGpathological examinationcomparative analysis

刘红军、尚丽、余五珍、张小燕、王守章

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嘉兴学院附属新安国际医院 神经内科,浙江 嘉兴 314031

上海德济医院 癫痫专科,上海 200331

嘉兴学院附属新安国际医院 急诊重症医学科,浙江 嘉兴 314031

药物 难治性癫痫 MRI 脑电图 病理 对照分析

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(10)
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