首页|慢性自身免疫性甲状腺炎少年儿童中胰岛β细胞自身抗体(GAD)的阳性率分析

慢性自身免疫性甲状腺炎少年儿童中胰岛β细胞自身抗体(GAD)的阳性率分析

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
目的 探讨慢性自身免疫性甲状腺炎患者中的抗胰岛细胞自身免疫状态.方法 用ELISA方法定量检测谷氨酸脱羧酶抗体,将慢性自身免疫性甲状腺炎学龄患儿的抗GAD抗体的频率和健康年对照组相比.结果 41例慢性自身免疫性甲状腺炎患者中4例(9.8%)为GAD抗体阳性.慢性自身免疫性甲状腺炎组GAD阳性率明显高于对照组,差异具有统计学意义(P<0.05).结论 研究发现,在自身免疫性甲状腺炎患者中GAD抗体阳性率较高.我们的发现支持了自身免疫性甲状腺疾病患者在未来生活中可能发展为1型糖尿病的概念.
The positive rate analysis of langerhans islets β-cells autoantibodies (anti-GAD) in young children with chronic autoimmune thyroiditis
Objective To explore the anti-islet cells in patients with chronic autoimmune thyroiditis. Methods Glutamate decarboxylase antibody was quantitatively detected by ELISA method, and the frequency of anti-GAD antibody in children with chronic autoimmune thyroiditis was compared with that in healthy control group. Results Of the 41 patients with chronic autoimmune thyroiditis, 4 (9.8%) were GAD antibody positive. The positive rate of GAD in chronic autoimmune thyroiditis group was significantly higher than that in the control group (P<0.05). Conclusion This study found that GAD antibody positive rate in patients with autoimmune thyroiditis was significantly higher. Our findings supported the concept of autoimmune thyroid disease patients who may develop into type 1 diabetes in future life.

type 1 diabetes mellitusautoimmune thyroid diseaseglutamate decarboxylase antibody (GAD)

李俊峰

展开 >

天津市第一中心医院 内分泌科,天津 300192

1型糖尿病 自身免疫性甲状腺病 谷氨酸脱羧酶抗体(GAD)

天津卫生和计划生育委员会中医和中西医结合科研课题

2015048

2017

10.3969/j.issn.1005-1678.2017.10.191

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN：1005-1678
年,卷(期)：2017.37(10)
  • 2
  • 16