肾素-血管紧张素-醛固酮抑制剂治疗糖尿病肾病的研究进展分析
Progress of research on the treatment of diabetic nephropathy with renin angiotensin aldosterone inhibitors
胡轩 1王琳琳2
作者信息
- 1. 天津华兴医院 内科, 天津 300270
- 2. 天津华兴医院 检验科,天津 300270
- 折叠
摘要
糖尿病是临床常见慢性病的一种,其发病后可导致多种并发症,糖尿病肾病就是其中之一,糖尿病的发病率逐年上升,因此糖尿病肾病的发病率也在逐年上升.肾素-血管紧张素-醛固酮系统(RAAS)的激活状态在该疾病的发生以及进展中具有重要意义,RAAS抑制剂对患者的血压有良好的控制作用,并且还可以减少尿蛋白,肾小球高滤过程度下降,其对肾间质纤维化也具有一定的抑制作用.研究结果显示RAAS抑制剂可延缓病情进展,终末期肾病发生率显著下降.本文将对糖尿病肾病治疗中RAAS抑制剂的应用进展进行综述,以加深对该药物及其对糖尿病肾病的临床治疗效果的了解.
Abstract
Diabetes is one of the most common clinical chronic diseases, the incidence can lead to a variety of complications, diabetic nephropathy is one of them, because the incidence of diabetes is increasing year by year, so the incidence of diabetic nephropathy also gradually upgrade. The activation of the renin-angiotensin-aldosterone system (RAAS) is important in the occurrence and progression of the disease. RAAS inhibitors have a good control over the patient's blood pressure and can also be reduced in urinary protein small ball high filtration degree decreased, its renal interstitial fibrosis also has a certain inhibitory effect. The study showed that the RAAS inhibitor slowed the progression of the disease, the incidence of end-stage renal disease decreased significantly. This article will elaborate and analyze the progress of the application of RAAS inhibitors in the treatment of diabetic nephropathy to help more researchers enhance their understanding and improve the clinical efficacy of diabetic nephropathy.
关键词
肾素-血管紧张素-醛固酮抑制剂/糖尿病肾病Key words
renin-angiotensin-aldosterone inhibitor/diabetic nephropathy引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据