Pharmacokinetic characteristics of pantoprazole sodium in rats with gastric ulcer after intravenous injection
Objective To investigate the pharmacokinetic characteristics of pantoprazole sodium in rats with gastric ulcer after intravenous injection. Methods 15 SD male rats were randomly divided into three groups: the model group, the sham operation group and the control group, 5 rats for each group. Rats in the control group did not take any treatment, but only served as a control group.The sham operation group performed laparotomy, but not the model. Rats in model group were made for gastric ulcer model. Three groups of rats were treated by tail intravenous injection of 10 mg/kg pantoprazole sodium, eye venous plexus blood of rats were separated before and after medication. Relevant pharmacokinetic characteristics were analyzed and calculated with the HPLC-UV method, and the stability and precision were verified. Results There was no statistical significance in pharmacokinetic parameters of CLz, AUC (0-t) and MRT (0-t) after intravenous injection of 10 mg/kg pantoprazole sodium in the three groups. In the range from 0.1 to 50.0 mg/L, the UV response showed a good pre correlation with the drug concentration, and the recovery rate of HPLC-UV was over 90.0%, which met the requirements of biological sample analysis. The analytical accuracy of pantoprazole sodium sample ranged from 86.0% to 116.0%, which met the requirements. Under different conditions, the theoretical value of pantoprazole sodium concentration is not significantly different from the measured value, and the stability met the requirements. Conclusion The pharmacokinetics of pantoprazole sodium in gastric ulcer rats is not significantly different from that in normal rats, and could be analyzed by HPLC-UV method.
pantoprazole sodiumgastric ulcer in ratspharmacokinetic characteristicsintravenous injection
NETL
NSTL
万方数据
维普
