首页|氨甲环酸在急性非静脉曲张性上消化道出血中的疗效评价

氨甲环酸在急性非静脉曲张性上消化道出血中的疗效评价

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目的 分析氨甲环酸在急性非静脉曲张性上消化道出血中的疗效.方法 选取金华文荣医院收治的86例急性非静脉曲张性上消化道出血患者为研究对象,随机分为对照组和实验组各43例.对照组给予埃索美拉唑,静脉使用.实验组在此基础上给予氨甲环酸,静脉滴注.比较分析2组患者的临床疗效、输血量及相关并发症发生情况.结果 经过对应治疗后,实验组治疗有效率为86.04%,高于对照组有效率(83.72%),2组比较差异无统计学意义.实验组与对照组患者人均输血量分别为(402.12±134.20)mL与(403.33±135.44)mL,2组比较差异无统计学意义.实验组患者发生心绞痛及短暂脑缺血发作的概率为11.63%,高于对照组(0%),2组比较差异具有统计学意义(P<0.05).结论 氨甲环酸在急性非静脉曲张性上消化道出血中的疗效并不理想,且可能增加心绞痛及短暂脑缺血等并发症发生概率.
Clinical evaluation of tranexamic acid in patients with acute nonvariceal upper gastrointestinal bleeding
Objective To study the analysis of tranexamic acid in patients with acute non variceal upper gastrointestinal bleeding in clinical evaluation. Methods 86 patients with acute non variceal upper gastrointestinal bleeding in Jinhua Grace Hospital were selected as the subjects. The control group was given intravenous esomeprazole. The experimental group was given intravenous drip of tranexamic acid. The clinical efficacy, blood transfusion and related complications of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, the effective rate was 86.04% in the experimental group and 83.72% in the control group. The difference between the two groups was not statistically significant. The blood transfusion volume of the patients in the experimental group and the control group was (402.12±134.20)mL and (403.33±135.44)mL, respectively, and there was no statistical significance. In the experimental group, the incidence of angina pectoris and transient ischemic attack was 11.63%, significantly higher than that of the control group (0%), with statistical difference (P<0.05). Conclusion Tranexamic acid in patients with acute nonvariceal upper gastrointestinal hemorrhage in is not ideal, and may increase the angina pectoris and transient ischemic complications such as probability.

tranexamic acidantifibrinolytic agentsupper gastrointestinal bleedingvariceal

陆丽娜、蒋国法、黄伟

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金华文荣医院 消化内科,浙江 金华 321000

氨甲环酸 抗纤溶剂 上消化道出血 静脉曲张

金华市科技计划社发类重点项目

2017-3-024

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(11)
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