重组人促红素β注射液联合维持控制护理模式对糖尿病肾病患者血液透析指标及生活质量的影响
Effect of recombinant human erythropoietin β injection combined with maintain control nursing model on hemodialysis indexes and quality of life in patients with diabetic nephropathy
邢亚利 1高倩1
作者信息
- 1. 绍兴市市立医院 内分泌科,浙江 绍兴 312000
- 折叠
摘要
目的 探讨重组人促红素β注射液联合维持控制护理模式对糖尿病肾病患者血液透析指标及生活质量的影响.方法 选择2013年4月~2015年6月绍兴市市立医院接诊的76例糖尿病肾病患者,通过随机数表法分为观察组(n=38)和对照组(n=38),2组均进行血液透析,在透析过程中,对照组给予维持控制护理模式,观察组再联合重组人促红素β注射液治疗,连续治疗1个月,比较2组治疗前后肾功能、血液透析指标以及生活质量的变化.结果 治疗后,2组尿蛋白排泄率(UAER)、血肌酐(SCr)较治疗前均得到显著降低(P<0.05),观察组UAER、SCr明显比对照组低,差异具有统计学意义(P<0.05).治疗后,2组尿素清除指数明显降低,血细胞压积明显升高(P<0.05),观察组尿素清除指数明显比对照组低,血细胞压积明显高于对照组,差异具有统计学意义(P<0.05).治疗后,2组生活质量量表各维度得分较治疗前均得到显著升高(P<0.05),观察组角色功能、躯体功能、情绪功能、社会功能得分以及总分均明显高于对照组,差异具有统计学意义(P<0.05).结论 在糖尿病肾病患者中使用重组人促红素β注射液联合维持控制护理模式,有助于改善肾功能及血液透析指标,提高生活质量.
Abstract
Objective To study the effect of recombinant human erythropoietin β injection combined with maintain control nursing model on hemodialysis indexes and quality of life in patients with diabetic nephropathy. Methods 76 patients of diabetic nephropathy who received therapy from April 2013 to June 2015 were selected as research objects. According to random number table, those patients were divided into the observation group (n=38) and the control group (n=38). Their were treated with hemodialysis, the control group was given maintenance control nursing mode, while the observation group was combined with recombinant human erythropoietin β injection, after one month of continuous treatment, the changes of renal function, hemodialysis index and quality of life were compared between the two groups before and after treatment. Results After treatment, the urinary protein excretion rate (UAER) and serum creatinine (SCr) of the two groups were significantly lower than those before treatment (P<0.05), the UAER and SCr in the observation group were significantly lower than those in the control group, the difference was statistically significant(P<0.05). After treatment, the urea clearance index of the two groups decreased significantly, and the hematocrit increased significantly (P<0.05), the urea clearance index in the observation group was significantly lower than those in the control group, and the hematocrit was higher than those in the control group, the difference was statistically significant(P<0.05) . After treatment, the quality of life scale scores in all dimensions of the two groups were significantly higher than those before treatment(P<0.05), the role function, physical function, emotional function, social function score and total score of the observation group were significantly higher than those in the control group, the difference was statistically significant(P<0.05). Conclusion Recombinant human erythropoietin β injection combined with maintain control nursing model is well for diabetic nephropathv, it is helpful to improve the renal function, hemodialysis indexes and the quality of life.
关键词
糖尿病肾病/维持控制护理/重组人促红素β注射液/血液透析指标/生活质量Key words
diabetic nephropathy/maintain control nursing model/recombinant human erythropoietin β injection/hemodialysis index/quality of life引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据