Observation on the effect of Bushen Zhuanggu Zhitong decoction on the treatment of degenerative osteoarthritis of the knee and the influence on IL-1β and TNF-α
Objective To investigate the clinical effect of Bushen Zhuanggu Zhitong decoction on the treatment of degenerative osteoarthritis of the knee and the influence on IL-1β and TNF-α. Methods A total of 60 patients with degenerative osteoarthritis of the knee were randomly divided into the control group (n=30) and the observation group(n=30). The control group were given Celecoxib Capsules combined with Glucosamine Hydrochloride Capsules, the observation group were treated with Bushen Zhuanggu Zhitong decoction combined with Glucosamine Hydrochloride Capsules, all treatment with eight weeks. The effect and IL-1β and TNF-α in the two groups were compared. Results After treatment, arthritis indexes, knee function, swelling index score and pain score in the observation group were lower than those in the control group (P<0.05). After treatment, IL-1β and TNF-α level in the observation group were lower than that in the control group (P<0.05). After treatment, there was no significance difference in drug adverse reaction in the two groups. Conclusion Degenerative osteoarthritis of the knee were treated by Bushen Zhuanggu Zhitong decoction combined with Glucosamine Hydrochloride Capsules, the effect is ideal.
NETL
NSTL
万方数据
维普
