伊曲康唑联合克霉唑栓治疗霉菌性阴道炎的疗效分析
Clinical analysis of itraconazole combined with clotrimazole suppositories in the treatment of mycotic vaginitis
余瑞梅 1马永萍 1廖珍华1
作者信息
- 1. 厦门大学附属第一医院思明分院 妇产科,福建 厦门 361000
- 折叠
摘要
目的 分析伊曲康唑联合克霉唑栓治疗霉菌性阴道炎的临床治疗效果.方法 选取厦门大学附属第一医院思明分院2014年10月~2016年10月收治的158例霉菌性阴道炎患者,按照入院顺序随机分为实验组(应用伊曲康唑联合克霉唑栓治疗方法,79例)与对照组(应用克霉唑栓治疗方法,66例).采用SPSS20.0统计学软件进行统计学分析2组患者的临床治疗总有效率、复发率以及不良反应发生率等参数指标.结果 实验组患者总有效率为96.20%;显著高于对照组患者的总有效率78.48%(P<0.05).实验组患者复发例数为2例,占2.53%;对照组患者复发例数为10例,占12.66%;实验组患者复发率远远低于对照组患者(P<0.05).实验组患者不良反应发生率为2.53%,对照组患者不良反应发生率为3.79%,2组患者的不良反应发生率比较无统计学意义.结论 伊曲康唑联合克霉唑栓治疗霉菌性阴道炎的临床治疗效果显著,复发率低以及不良反应少.
Abstract
Objective To analyze the clinical efficacy of itraconazole combined with clotrimazole suppositories in the treatment of mycotic vaginitis. Methods 158 cases of mycotic vaginitis patients from January 2015 to December 2016 were treated in Siming branch of the First Affiliated of Xiamen University, as the study objects, were randomly divided into the observation group and the control group according to the digital table method, 50 cases for each group. The observation group was treated with itraconazole combined with clotrimazole suppositories treatment, the control group was given clotrimazole suppositories treatment. The clinical efficacy, recurrence rate, adverse reactions rates of the two groups were compared by SPSS20.0. Results The total effective rate in the experimental group was 96.20%, significantly higher than 78.48% of the control group (P<0.05). In the experimental group, the recurrence number of patients was 2 cases, accounting for 2.53%. The number of recurrent cases in the control group was 10, accounting for 12.66%. The recurrence rate in the experimental group was significantly lower than that in the control group (P<0.05). The incidence of adverse reactions in the experimental group was 2.53%, and the incidence of adverse reactions in the control group was 3.79%, and the incidence of adverse reactions in the two groups was not statistically significant. Conclusion Itraconazole combined with clotrimazole suppositories in the treatment of mycotic vaginitis has good clinical efficacy with low recurrence rate and low adverse reaction.
关键词
伊曲康唑/克霉唑栓/霉菌性阴道炎Key words
itraconazole/clotrimazole suppositories/mycotic vaginitis引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据