Effects of intravenous anesthesia with Etomidate on cognitive function and intraoperative stress response in elderly orthopedic patients
Objective To investigate the safety of intravenous anesthesia with Etomidate in elderly orthopedic patients. Methods 150 cases of elderly orthopedic patients from March 2015 to March 2017 were divided into the control group and the observation group according to the random number table method, 75 cases for each group. All patients were treated with intravenous anesthesia, in which the control group was induced with propofol and maintained anesthesia; the observation group was given Etomidate induced and maintained anesthesia. The complications of the two groups were recorded at the first day and the seventh days after operation. The levels of cortisol were measured before anesthesia, the complete time of operation and 24 hours after operation. Results The complication rate in the observation group was 21.33% (16/75) compared with 26.67% (20/75) in the control group; the cognitive impairment rate was 24.6% (18/75) and 12.0% (9/75) of the control group, the cognitive dysfunction rate was 26.67% and 13.33%, and there was no significant difference between two groups. The concentration of cortisol in the two groups was significantly lower than that before operation, and the concentration of cortisol in the observation group was significantly lower than the control group (P<0.05). There was no significant difference in the concentration of cortisol restoring to preoperative levels at 24h after operation in two groups. Conclusion The application of Etomidate in elderly orthopedic surgery with intravenous anesthesia could not increase the incidence of cognitive dysfunction in patients, however, inhibition of stress response of Etomidate was better than propofol.
Etomidategeriatricdepartment of orthopedicpropofol
NETL
NSTL
万方数据
维普
