Effects of dexmedetomidine on the amount of narcotic drugs and stress response in elderly patients
Objective The purpose of this study was to investigate the effects of dexmedetomidine on the amount of narcotic drugs and stress response in elderly patients. Methods 80 cases of elderly patients undergoing hip replacement in our hospital from February 2015 to August 2016 were randomly divided into the control group and the experimental group, with 40 patients in each group. The patients in the experimental group received 0.5 μg / kg dexmedetomidine before anesthesia induction, with a duration of 15min and a speed of 0.5 μg / (kg?h) until the end of surgery, 0.5 h. The control group was given the same volume of normal saline. The stress response and dosage of narcotic drugs in the experimental group and the control group were compared and analyzed. Results The experimental group of propofol and sufentanil respectively (520.72 ± 112.47) mg and (44.20 ±13.62) ug control group, propofol and sufentanil respectively (812.32 ± 201.32) mg and (60.14 ± 15.72) μg, with statistical difference (P<0.05). Before anesthesia induction, there was no significant difference between the two groups in cortisol levels and IL-6 levels. After the operation, the cortisol level and IL-6 level of the experimental group were significantly lower than that of the control group (0.5h), and the difference was statistically significant (P<0.05). Conclusion Dexmedetomidine can significantly reduce the dosage of anesthesia drugs propofol and sufentanil in elderly patients, and reduce the stress response to a great extent.
dexmedetomidinesurgerydosage of narcotic drugsstress responseelderly patients
NETL
NSTL
万方数据
维普
