Effects of adjuvant immunochemotherapy with astragalus injection on the immunologic function and serum tumor molecule of endometrial cancer patients
Objective To explore the effects of adjuvant immunochemotherapy with astragalus injection on the immune function and serum tumor molecule of endometrial cancer patients. Methods 112 cases endometrial cancer patients were selected from May 2014 to October 2016 as the study object and divided into observation group (n=56) and control group (n=56) randomly. The control group was treated with regular chemotherapy, and the observation group was treated with astragalus injection on the basis of control group. Compared the clinical efficacy of 2 groups, deceted and compared the immune function and levels of serum tumor molecule before and after chemotherapy in 2 groups, statisticsed the incidence of toxicity in 2 groups. Results The remission rate of the observation group was 73.22%, which was significant higher than 51.79% of the control group after chemotherapy (P<0.01). Compared with before chemotherapy, the CD4+, CD8+ proportion in peripheral blood of 2 groups decreased, and the reduction extent of observation group was less than control group, the CD4+/CD8+ in peripheral blood of the control group decreased significantly, and which was lower than the observation group (P<0.01). The serum IgG, IgA of 2 groups had no obvious change, but observation group was higher than control group (P<0.05). Compared with before chemotherapy, the levels of serum IgM and complement C3 of the observation group increased, IgM and complement C3 of the control group decreased after chemotherapy, and the observation group was higher than the control group (P<0.05 or P<0.01). The Incidence of gastrointestinal reaction, granulocytopenia, thrombopenia, hepatic and renal dysfunction of the observation group was lower than those of the control group during chemotherapy (P<0.05 or P<0.01). Conclusion Adjuvant immunochemotherapy with astragalus injection can improve the clinical efficacy, reduce the levels of serum tumor molecular, avoid the damage of chemotherapy to the immune function of organism, reduce the toxicity, security is good.
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