Effect of dexmedetomidine on cognitive function after general thoracic surgery in elderly patients
Objective To investigate the effect of dexmedetomidine on postoperative cognitive function in elderly patients in General Department of thoracic surgery. Methods 90 elderly patients with general thoracic surgery operation collected from November 2015 to December 2016 in our hospital were randomly divided into two groups according to the different use of drugs, Two groups of patients underwent surgical treatment, the control group received intravenous infusion of normal saline before induction of anesthesia, the study group received intravenous infusion of dexmedetomidine in operation before anesthesia induction,The hemodynamic indexes and postoperative cognitive function of the 2 groups were compared. Results In the course of surgical treatment, there were no significant differences in hemodynamic parameters between the 2 groups before anesthesia, During operation and after operation, the hemodynamic parameters of HR, SBP and DBP in the study group were significantly better than those in the control group (P<0.05). The operation time of the study group was higher than that of the control group, but the amount of bleeding and the recovery time of the study group were lower than that of the control group (P<0.05). The simplified psychiatric status scale (MMSE) score in the study group was significantly higher than that in the control group first, second, third days after the operation (P<0.05). Conclusion Dexmedetomidine can improve the hemodynamic indexes and postoperative cognitive function in elderly patients undergoing general department of thoracic surgery operation, and is worthy of further promotion and application.
elderly patientsthoracic surgerydextroidinecognitive function
NETL
NSTL
万方数据
维普
