右美托咪定对老年患者普通胸外科手术后认知功能的影响
Effect of dexmedetomidine on cognitive function after general thoracic surgery in elderly patients
余良胜 1管全胜 1谈海云1
作者信息
摘要
目的 探讨右美托咪定对老年患者普通胸外科手术后认知功能的影响.方法 选取2015年11月~2016年12月黄石市爱康医院收治的老年普通胸外科手术患者90例,依据使用药物的不同随机分为2组,每组45例.2组患者均手术治疗,对照组麻醉诱导前静脉泵注生理盐水,研究组在麻醉诱导前静脉泵注右美托咪定,对比2组患者在术中的血流动力学指标以及术后的认知功能.结果 在手术治疗的过程中,麻醉前2组患者血流动力学各指标差异无统计学意义,手术过程中及术后,研究组患者的HR、SBP与DBP血流动力指标明显优于对照组;研究组的手术时间高于对照组,但术中出血量和苏醒时间都明显低于对照组(P<0.05);研究组患者的简易精神状态检查量表(MMSE)评分在手术治疗后第1、2、3天后明显高于对照组(P<0.05).结论 右美托咪定对老年普通胸外科手术患者的治疗中,可以改善患者术中的血流动力指标以及术后的认知功能.
Abstract
Objective To investigate the effect of dexmedetomidine on postoperative cognitive function in elderly patients in General Department of thoracic surgery. Methods 90 elderly patients with general thoracic surgery operation collected from November 2015 to December 2016 in our hospital were randomly divided into two groups according to the different use of drugs, Two groups of patients underwent surgical treatment, the control group received intravenous infusion of normal saline before induction of anesthesia, the study group received intravenous infusion of dexmedetomidine in operation before anesthesia induction,The hemodynamic indexes and postoperative cognitive function of the 2 groups were compared. Results In the course of surgical treatment, there were no significant differences in hemodynamic parameters between the 2 groups before anesthesia, During operation and after operation, the hemodynamic parameters of HR, SBP and DBP in the study group were significantly better than those in the control group (P<0.05). The operation time of the study group was higher than that of the control group, but the amount of bleeding and the recovery time of the study group were lower than that of the control group (P<0.05). The simplified psychiatric status scale (MMSE) score in the study group was significantly higher than that in the control group first, second, third days after the operation (P<0.05). Conclusion Dexmedetomidine can improve the hemodynamic indexes and postoperative cognitive function in elderly patients undergoing general department of thoracic surgery operation, and is worthy of further promotion and application.
关键词
老年患者/胸外科手术/右美托咪定/认知功能Key words
elderly patients/thoracic surgery/dextroidine/cognitive function引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据