首页|经颅超声溶栓联合阿托伐他汀钙治疗动脉粥样硬化性脑梗死的临床疗效

经颅超声溶栓联合阿托伐他汀钙治疗动脉粥样硬化性脑梗死的临床疗效

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目的 分析经颅超声溶栓联合阿托伐他汀钙治疗动脉粥样硬化性脑梗死的临床效果.方法 选取2014年1月~2017年9月延安市洛川县医院收治的120例动脉粥样硬化性脑梗死患者为研究对象,随机分为对照组和实验组,每组各60例.2组患者均进行常规治疗,对照组给予阿托伐他汀钙,口服,每天20 mg.实验组在此基础上给予经颅超声溶栓治疗,2次/天,一次为20 min.比较分析实验组与对照组患者高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)及颈动脉斑块等临床指标.结果 治疗后,实验组患者IMT为(1.01±0.32)mm显著小于对照组为(1.42±0.52)mm(P<0.05).治疗后,实验组NIHSS评分为(7.32±1.67),对照组NIHSS评分为(10.32±1.68)分(P<0.05).治疗后,实验组HDL-C水平为(2.14±0.23)mmol/L显著高于对照组为(1.98±0.20)mmol/L,另外,实验组总胆固醇(TC)、三酰甘油(TG)及LDL-C水平均显著优于对照组(P<0.05).结论 经颅超声溶栓联合阿托伐他汀钙治疗动脉粥样硬化性脑梗死临床效果理想,可显著改善患者血脂水平,帮助患者恢复健康,缓解动脉粥样硬化.
Clinical efficacy of transcranial ultrasound thrombolysis combined with atorvastatin calcium in the treatment of atherosclerotic cerebral infarction
Objective To study and analyze the clinical effect of transcranial ultrasound thrombolysis combined with atorvastatin calcium in the treatment of atherosclerotic cerebral infarction. Methods Selected 120 patients with atherosclerotic cerebral infarction during January 2014 to September 2017 treated in Luochuan County Hospital were divided into control group and experimental group, 60 cases in each group. The two groups were treated with routine treatment, and the control group was given atorvastatin calcium, 20 mg per day, oral. The experimental group received transcranial ultrasound thrombolysis on the basis of control group, 2 times per day, once for 20 minutes. The clinical indicators such as high-density lipoprotein cholesterol, total cholesterol and carotid plaque index were compared and analyzed in the experimental group and the control group. Results After treatment, the IMT in the experimental group was (1.01±0.32) mm significantly smaller than that in the control group (1.42±0.52) mm (P<0.05). After treatment, the score of NIHSS in the experimental group was (7.32±1.67), and the score of NIHSS in the control group was (10.32±1.68), with statistical difference (P<0.05). After treatment, the experimental group HDL-C level (2.14±0.23) mmol/L, significantly higher than the control group (1.98±0.20) mmol/L. In addition, the average level of total cholesterol, triglyceride and LDL-C in the experimental group was better than the control group (P<0.05). Conclusion Transcranial ultrasound thrombolysis combined with atorvastatin calcium in the treatment of atherosclerotic cerebral infarction clinical effect is ideal,can significantly improve the lipid level of patients, help patients recover, alleviate atherosclerosis.

transcranial ultrasound thrombolysisatorvastatin calciumatherosclerotic cerebral infarction

李晓艳、周平安

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延安市洛川县医院 超声科,陕西 延安 727400

延安大学附属医院 超声科,陕西 延安 716000

经颅超声溶栓 阿托伐他汀钙 动脉粥样硬化性脑梗死

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(11)
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