Objective to compare the effects of different doses of dexmedetomidine on elderly patients undergoing anterior cervical spine surgery under general anesthesia
Objective To compare the clinical effects of different doses of dexmedetomidine on general anesthesia in elderly patients with anterior cervical spine surgery. Methods 40 elderly patients with anterior cervical surgery from February 2015 to March 2017 in the Second Affiliated Hospital of Wenzhou Medical University were randomly divided into control group and observation group, the control group were treated with 0.8 μg/kg the dose of dexmedetomidine, the observation group used 0.6 μg/kg doses of dexmedetomidine, and compared the hemodynamics,the changes of somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) in two groups of patients. Results The heart rate (HR), mean arterial pressure (MAP), brain bispectral index (BIS) decreased significantly (P<0.05) compared with that of post-treatment;the observation group of patients with HR, MAP, BIS detection value is relatively high. And the two groups of SEPs amplitude and the latency were compared, results showed that the difference was not statistically significant, and control groups were compared, the SEPs amplitude and latency of observation group are obvious decreased; the success rate of monitoring of SEPs, MEPs, and intraoperative awareness were compared for all patients,the results showed that the difference was not statistically significant. Conclusion It is less effect for SEPs, hemodynamics, and MEPs for patients, the dose control in 0.6 μg/kg for elderly patients with cervical anterior surgery under general anesthesia with dexmedetomidine intravenous infusion has significant clinical curative effect.