首页|病原微生物检测联合药敏试验对细菌性腹泻患儿抗生素合理使用的影响

病原微生物检测联合药敏试验对细菌性腹泻患儿抗生素合理使用的影响

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目的 探讨病原微生物检测联合药敏试验对细菌性腹泻患儿抗生素合理使用的影响.方法 选取2015年10月~2017年6月浙江省杭州市萧山区中医骨伤科医院收治的147例细菌性腹泻患儿作为研究对象,均于入院后采集患儿粪便标本,进行病原微生物检测及药敏试验,分析病原微生物分布及其对抗生素耐药情况.结果 147例细菌性腹泻患儿共检出132株病原微生物,其中志贺菌构成比为46.21%(61/132)、致泻大肠杆菌占22.73%(30/132)、弧菌属占15.91%(21/132)、嗜水气单胞菌占8.33%(11/132)、其他菌株占6.82%(9/132);各类病原微生物对不同抗生素均具有一定耐药性,弧菌属及嗜水气单胞菌对氨苄西林耐药性较强,分别为90.48%(19/21)、81.82%(9/11).结论 对细菌性腹泻患儿进行病原微生物检测与药敏试验,可准确掌握病原微生物分布及其对常用抗生素耐药情况,有利于指导抗生素的合理运用.
Effect of pathogenic microbiological detection combined with drug sensitivity test on rational use of antibiotics in children with bacterial diarrhea
Objective To investigate the effect of pathogenic microbiological detection combined with drug susceptibility test on the rational use of antibiotics in children with bacterial diarrhea. Methods From October 2015 to June 2017, 147 cases of children with bacterial diarrhea in our hospital were selected as the study object, the stool samples were collected after admission, then pathogenic microbiological testing and drug susceptibility testing was conduct to analyze pathogenic microbial distribution and its resistance to antibiotics. Results 132 strains of pathogenic microorganisms were detected from all the 147 cases of bacterial diarrhea in children, the composition ratio of Shigella was 46.21% (61/132), Escherichia coli accounting for 22.73% (30/132), Vibrio accounted for 15.91% (21/132), aeromonas aeruginosa accounted for 8.33% (11/132), other strains accounted for 6.82% (9/132). All kinds of pathogenic microorganisms were resistant to different antibiotics. Vibrio and Aeromonas hydrophila were resistant to ampicillin, which were 90.48% (19/21), 81.82% (9/11), respectively. Conclusion Pathogenic microbial detection and drug sensitivity test in children with bacterial diarrhea can accurately grasp the distribution of pathogenic microorganisms and antibiotic resistance to commonly used antibiotics, it is conducive to guiding the rational use of antibiotics.

bacterial diarrheapathogenic microorganismsdrug susceptibility testantibioticsrational use

俞国燕

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浙江省杭州市萧山区中医骨伤科医院,浙江 杭州 310000

细菌性腹泻 病原微生物 药敏试验 抗生素 合理使用

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(11)
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