首页|噻托溴铵联合舒利迭治疗慢性阻塞性肺疾病稳定期患者的临床疗效

噻托溴铵联合舒利迭治疗慢性阻塞性肺疾病稳定期患者的临床疗效

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目的 分析噻托溴铵联合舒利迭治疗慢性阻塞性肺疾病稳定期患者的临床疗效.方法 选取天津市第四中心医院2015年6月~2017年5月收治的80例慢性阻塞性肺疾病稳定期患者为研究对象,随机分为2组,每组各40例.对照组采用噻托溴铵治疗,实验组进行噻托溴铵联合舒利迭治疗.比较实验组与对照组治疗前后的动脉二氧化碳分压、氧分压及FEV1和FEV1/FVC.结果 治疗后,实验组FEV1为(2.27±0.45)L显著高于对照组的(1.80±0.20)L(P<0.05).实验组FEV1/FVC为(68.90±5.22),对照组FEV1/FVC为(54.33±4.20),2组比较差异具有统计学意义(P<0.05).实验组经过治疗后,氧分压为(75.09±6.33)mmHg显著高于对照组氧分压(66.33±4.76)mmHg(P<0.05),动脉二氧化碳(44.30±2.67)mmHg显著低于对照组(P<0.05).结论 噻托溴铵联合舒利迭治疗慢性阻塞性肺疾病稳定期患者的临床疗效较为理想,可显著改善患者肺功能,缓解临床症状.
Clinical effect of tiotropium combined with Seretide in the treatment of patients with chronic obstructive pulmonary diseases
Objective To study the clinical efficacy of tiotropium combined with Seretide in the treatment of patients with chronic obstructive pulmonary diseases. Methods 80 cases of patients with stable chronic obstructive pulmonary disease patients treated in our hospital from June 2015 to May 2017 as the research object, they were randomly divided into two groups, with 40 cases in each group. The control group was treated with tiotropium bromide, the experimental group was treated with tiotropium combined with Seretide. The arterial carbon dioxide partial pressure, oxygen partial pressure, FEV1 and FEV1,/FVC were compared between the experimental group and the control group before and after treatment. Results After the corresponding treatment, FEV1 in the experimental group was (2.27±0.45) L, significantly higher than that of the control group (1.80± 0.20) L (P<0.05). The FEV1 /FVC in the experimental group was (68.90±5.22), in the control group was (54.33±4.20), the difference between the two groups was statistically significant (P<0.05). After treatment, the oxygen partial pressure in the experimental group was(75.09±6.33) mmHg, which was significantly higher than that in the control group (66.33±4.76) mmHg (P<0.05). The arterial carbon dioxide in the experimental group was (44.30±2.67) mmHg, which was significantly lower than that in the control group(P<0.05). Conclusion The clinical effect of tiotropium combined with Seretide in the treatment of patients with chronic obstructive pulmonary disease is ideal, can significantly improve the pulmonary function of patients, relieve the clinical symptoms.

tiotropium bromideSeretidechronic obstructive pulmonary disease

彭秋凤、高静珍、邢爱民

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天津市第四中心医院 呼吸内科,天津 300140

噻托溴铵 舒利迭 慢性阻塞性肺疾病稳定期

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(11)
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